Synthesis of New Mannich Bases from Indole Derivatives
This work includes two steps of synthesis, the first one is the synthesis of indole which was prepared according to literature of the reaction of phenyl hydrazine with acetaldehyde in glacial acetic acid afforded phenyl hydrazone of acetaldehyde , this product was fused with zinc chloride to give th...
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University of Baghdad, College of Science for Women
2012-03-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1348 |
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| description | This work includes two steps of synthesis, the first one is the synthesis of indole which was prepared according to literature of the reaction of phenyl hydrazine with acetaldehyde in glacial acetic acid afforded phenyl hydrazone of acetaldehyde , this product was fused with zinc chloride to give the indole.Reaction of cyclohexanone with phenyl hydrazine using the same procedure for the preparing giving 1,2,3,4-Tetrahydrocarbazole.Second step involved synthesis of a series of (17) of mannich bases derivatives of indole and 1,2,3,4-Tetrahydrocarbazle. Mannich reaction involves the condensation of aldehyde usually formaldehyde with different secondary amine and with compound containing an activated hydrogen.The reaction illustrated by the following equation :R2NH+HCHO+RH?R2N-CH2-R+H2O These compounds were characterized by U.V , FT-IR and 1H-NMR spectra for two compounds. The secondary amines that used to prepare mannich bases are:N-methyl –N-phenyl amine, N,N-dimethyl amine, N,N- diphenyl amine, N-ethyl –N- phenyl amine, N,N-di-n-propyl amine, pyrrolidine, morpholine, N- methyl pipyridine, N,N-dibenzyl amine, N,N-di –n-butyl amine and N,N-di ethyl amine. |
| format | Article |
| id | doaj-art-ae3690fb57a14a7fad60ee8a6bb6ba75 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2012-03-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-ae3690fb57a14a7fad60ee8a6bb6ba752025-08-20T02:51:10ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862012-03-019110.21123/bsj.9.1.168-177Synthesis of New Mannich Bases from Indole DerivativesBaghdad Science JournalThis work includes two steps of synthesis, the first one is the synthesis of indole which was prepared according to literature of the reaction of phenyl hydrazine with acetaldehyde in glacial acetic acid afforded phenyl hydrazone of acetaldehyde , this product was fused with zinc chloride to give the indole.Reaction of cyclohexanone with phenyl hydrazine using the same procedure for the preparing giving 1,2,3,4-Tetrahydrocarbazole.Second step involved synthesis of a series of (17) of mannich bases derivatives of indole and 1,2,3,4-Tetrahydrocarbazle. Mannich reaction involves the condensation of aldehyde usually formaldehyde with different secondary amine and with compound containing an activated hydrogen.The reaction illustrated by the following equation :R2NH+HCHO+RH?R2N-CH2-R+H2O These compounds were characterized by U.V , FT-IR and 1H-NMR spectra for two compounds. The secondary amines that used to prepare mannich bases are:N-methyl –N-phenyl amine, N,N-dimethyl amine, N,N- diphenyl amine, N-ethyl –N- phenyl amine, N,N-di-n-propyl amine, pyrrolidine, morpholine, N- methyl pipyridine, N,N-dibenzyl amine, N,N-di –n-butyl amine and N,N-di ethyl amine.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1348"Indole, Mannich bases, Reaction of indole, Mechanism of mannich base" |
| spellingShingle | Baghdad Science Journal Synthesis of New Mannich Bases from Indole Derivatives مجلة بغداد للعلوم "Indole, Mannich bases, Reaction of indole, Mechanism of mannich base" |
| title | Synthesis of New Mannich Bases from Indole Derivatives |
| title_full | Synthesis of New Mannich Bases from Indole Derivatives |
| title_fullStr | Synthesis of New Mannich Bases from Indole Derivatives |
| title_full_unstemmed | Synthesis of New Mannich Bases from Indole Derivatives |
| title_short | Synthesis of New Mannich Bases from Indole Derivatives |
| title_sort | synthesis of new mannich bases from indole derivatives |
| topic | "Indole, Mannich bases, Reaction of indole, Mechanism of mannich base" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1348 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisofnewmannichbasesfromindolederivatives |