Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction

Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction

Abstract The metastasis of lung cancer represents a significant factor contributing to the failure of clinical treatment, and the mechanisms involved are intricate and not yet completely elucidated. Intermediate filaments, which constitute a key element of the cytoskeleton, function not only as diag...

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Main Authors: Yuanling Ye, Fan Shen, Maoli Yan, Conghui Zhan, Jiahua Lv, Mengqin Zou, Zhifeng Wang, Shaokai Ning, Yanfei Gao, Jingxian Wu, Wen Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07846-z
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