Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine

Cladribine is a purine nucleoside analog which initiates the apoptotic mechanism within cells. Moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the Bcl-2 family, also induces the activation of the intrinsic ap...

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Main Authors: Ewelina Wawryk-Gawda, Patrycja Chylińska-Wrzos, Marta Lis-Sochocka, Kamila Bulak, Barbara Jodłowska-Jędrych
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2014/928036
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author Ewelina Wawryk-Gawda
Patrycja Chylińska-Wrzos
Marta Lis-Sochocka
Kamila Bulak
Barbara Jodłowska-Jędrych
author_facet Ewelina Wawryk-Gawda
Patrycja Chylińska-Wrzos
Marta Lis-Sochocka
Kamila Bulak
Barbara Jodłowska-Jędrych
author_sort Ewelina Wawryk-Gawda
collection DOAJ
description Cladribine is a purine nucleoside analog which initiates the apoptotic mechanism within cells. Moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the Bcl-2 family, also induces the activation of the intrinsic apoptosis pathway. However, while there has been a lot of research devoted to the effect of cladribine on lymphatic system cells, little is known about the impact of cladribine on the reproductive system. The aim of our study was to evaluate apoptosis in oviduct epithelial cells sourced from 15 different female rats. In so doing, the sections were stained with caspases 3, 9, and 8. Results suggest that cladribine also induces apoptosis in the oviduct epithelial cells by way of the intrinsic pathway. Indeed, the discontinuing of the administration of cladribine leads to a reduction in the amount of apoptotic cells in the oviduct epithelium.
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institution Kabale University
issn 2356-6140
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language English
publishDate 2014-01-01
publisher Wiley
record_format Article
series The Scientific World Journal
spelling doaj-art-ae28a520d3864110b16f6feea526f4542025-02-03T01:26:16ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/928036928036Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by CladribineEwelina Wawryk-Gawda0Patrycja Chylińska-Wrzos1Marta Lis-Sochocka2Kamila Bulak3Barbara Jodłowska-Jędrych4Chair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandChair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandChair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandChair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandChair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandCladribine is a purine nucleoside analog which initiates the apoptotic mechanism within cells. Moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the Bcl-2 family, also induces the activation of the intrinsic apoptosis pathway. However, while there has been a lot of research devoted to the effect of cladribine on lymphatic system cells, little is known about the impact of cladribine on the reproductive system. The aim of our study was to evaluate apoptosis in oviduct epithelial cells sourced from 15 different female rats. In so doing, the sections were stained with caspases 3, 9, and 8. Results suggest that cladribine also induces apoptosis in the oviduct epithelial cells by way of the intrinsic pathway. Indeed, the discontinuing of the administration of cladribine leads to a reduction in the amount of apoptotic cells in the oviduct epithelium.http://dx.doi.org/10.1155/2014/928036
spellingShingle Ewelina Wawryk-Gawda
Patrycja Chylińska-Wrzos
Marta Lis-Sochocka
Kamila Bulak
Barbara Jodłowska-Jędrych
Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine
The Scientific World Journal
title Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine
title_full Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine
title_fullStr Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine
title_full_unstemmed Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine
title_short Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine
title_sort intrinsic apoptosis pathway in fallopian tube epithelial cells induced by cladribine
url http://dx.doi.org/10.1155/2014/928036
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