A Histopathological and Immunohistochemical Analysis of Ameloblastic Fibrodentinoma
Ameloblastic fibrodentinoma (AFD) is considered a mixed odontogenic tumor that is characterized by conserved epithelial and ectomesenchymal neoplastic components. AFD is composed of long narrow cords and islands of odontogenic epithelium; the epithelial strands lie in a myxoid cell-rich ectomesenchy...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2013/604560 |
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| author | Ronell Bologna-Molina Sirced Salazar-Rodríguez Ana María Bedoya-Borella Ramón Gil Carreón-Burciaga Gabriel Tapia-Repetto Nelly Molina-Frechero |
| author_facet | Ronell Bologna-Molina Sirced Salazar-Rodríguez Ana María Bedoya-Borella Ramón Gil Carreón-Burciaga Gabriel Tapia-Repetto Nelly Molina-Frechero |
| author_sort | Ronell Bologna-Molina |
| collection | DOAJ |
| description | Ameloblastic fibrodentinoma (AFD) is considered a mixed odontogenic tumor that is characterized by conserved epithelial and ectomesenchymal neoplastic components. AFD is composed of long narrow cords and islands of odontogenic epithelium; the epithelial strands lie in a myxoid cell-rich ectomesenchymal tissue with stellate-shaped fibroblasts that exhibit long slender cytoplasmic extensions that resemble dental papilla. The lesions show the presence of dysplastic dentin. Although AFD is a rare entity and its very existence is not completely accepted, based on the extent of histodifferentiation, it is considered to represent a stage between ameloblastic fibroma and ameloblastic fibroodontoma. This study aimed to provide a histopathological and immunohistochemical characterization of this infrequent tumor. A large panel of antibodies including amelogenin, Ck 19, calretinin, syndecan-1, E-cadherin, MSH2, histone H3, and Ki-67 was used to illustrate the nature of the tumor. |
| format | Article |
| id | doaj-art-ae25d7b1c1304245a664bbf785249d65 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-ae25d7b1c1304245a664bbf785249d652025-02-03T01:03:37ZengWileyCase Reports in Pathology2090-67812090-679X2013-01-01201310.1155/2013/604560604560A Histopathological and Immunohistochemical Analysis of Ameloblastic FibrodentinomaRonell Bologna-Molina0Sirced Salazar-Rodríguez1Ana María Bedoya-Borella2Ramón Gil Carreón-Burciaga3Gabriel Tapia-Repetto4Nelly Molina-Frechero5Oral Pathology, Research Department, School of Dentistry, Universidad Juárez del Estado de Durango (UJED), 34000 Durango, DGO, MexicoPathology Department, Instituto Nacional de Oncología y Radiobiología (INOR), 10400 Havana, CubaBiology Department, CBC, Universidad de Buenos Aires (UBA), 8000 Buenos Aires, ArgentinaOral Pathology, Research Department, School of Dentistry, Universidad Juárez del Estado de Durango (UJED), 34000 Durango, DGO, MexicoSchool of Dentistry, Universidad de la República (UDELAR), 19200 Montevideo, UruguayHealth Care Department, Universidad Autónoma Metropolitana, Xochimilco, 04960 Mexico City, DF, MexicoAmeloblastic fibrodentinoma (AFD) is considered a mixed odontogenic tumor that is characterized by conserved epithelial and ectomesenchymal neoplastic components. AFD is composed of long narrow cords and islands of odontogenic epithelium; the epithelial strands lie in a myxoid cell-rich ectomesenchymal tissue with stellate-shaped fibroblasts that exhibit long slender cytoplasmic extensions that resemble dental papilla. The lesions show the presence of dysplastic dentin. Although AFD is a rare entity and its very existence is not completely accepted, based on the extent of histodifferentiation, it is considered to represent a stage between ameloblastic fibroma and ameloblastic fibroodontoma. This study aimed to provide a histopathological and immunohistochemical characterization of this infrequent tumor. A large panel of antibodies including amelogenin, Ck 19, calretinin, syndecan-1, E-cadherin, MSH2, histone H3, and Ki-67 was used to illustrate the nature of the tumor.http://dx.doi.org/10.1155/2013/604560 |
| spellingShingle | Ronell Bologna-Molina Sirced Salazar-Rodríguez Ana María Bedoya-Borella Ramón Gil Carreón-Burciaga Gabriel Tapia-Repetto Nelly Molina-Frechero A Histopathological and Immunohistochemical Analysis of Ameloblastic Fibrodentinoma Case Reports in Pathology |
| title | A Histopathological and Immunohistochemical Analysis of Ameloblastic Fibrodentinoma |
| title_full | A Histopathological and Immunohistochemical Analysis of Ameloblastic Fibrodentinoma |
| title_fullStr | A Histopathological and Immunohistochemical Analysis of Ameloblastic Fibrodentinoma |
| title_full_unstemmed | A Histopathological and Immunohistochemical Analysis of Ameloblastic Fibrodentinoma |
| title_short | A Histopathological and Immunohistochemical Analysis of Ameloblastic Fibrodentinoma |
| title_sort | histopathological and immunohistochemical analysis of ameloblastic fibrodentinoma |
| url | http://dx.doi.org/10.1155/2013/604560 |
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