Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism
IntroductionStudies have revealed that Tai Chi can enhance cognitive functions among patients with mild cognitive impairment (MCI). However, the precise mechanisms underlying this improvement remain elusive.MethodsConsequently, we conducted a study involving 54 elderly inpatients with MCI residing i...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1435996/full |
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| author | Lin Lin Lin Lin Yao-Xi He Quan Wen Jia-Yang Liu Yu Dai Yu-Zhe Fei Hang Li Chang-Qing Li Huan Zhou Huan Zhou |
| author_facet | Lin Lin Lin Lin Yao-Xi He Quan Wen Jia-Yang Liu Yu Dai Yu-Zhe Fei Hang Li Chang-Qing Li Huan Zhou Huan Zhou |
| author_sort | Lin Lin |
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| description | IntroductionStudies have revealed that Tai Chi can enhance cognitive functions among patients with mild cognitive impairment (MCI). However, the precise mechanisms underlying this improvement remain elusive.MethodsConsequently, we conducted a study involving 54 elderly inpatients with MCI residing in a combined medical and elderly care facility in Chengdu, who were randomly divided into three groups: a control group engaging in daily living activities, a Tai Chi group that performed Tai Chi exercises in addition to control group activities, and a walking group that undertook walking activities as a supplement to the control group regimen. The intervention period lasted for 24 weeks, comprising 12 weeks of exercise and an additional 12 weeks of follow-up. The Montreal Cognitive Assessment (MoCA), Trail Making Test-A (TMT-A), Auditory Verbal Learning Test (AVLT), and biochemical assessments (measuring brain-derived neurotrophic factor, BDNF, and platelet factor 4, PF4) were administered to investigate overall cognitive function, executive function, memory capacity, and changes in serum concentrations of BDNF and PF4 before, after, and during the follow-up period. Data were analyzed using IBM SPSS 26.0, with statistical methods encompassing descriptive analysis, ANOVA, rank-sum test, repeated measures ANOVA, and generalized estimating equations.ResultsOur findings indicated that after 24 weeks of intervention, the Tai Chi group exhibited improvements in cognitive function, executive function, and memory compared to the control group. This enhancement may be attributed to an increased expression of serum BDNF.DiscussionIn conclusion, our study underscores the potential of Tai Chi in ameliorating cognitive function among elderly patients with mild cognitive impairment, thereby offering significant implications for clinical prevention and treatment strategies targeting this condition. |
| format | Article |
| id | doaj-art-ae210540c00c48caa3f26a242302cd2e |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-ae210540c00c48caa3f26a242302cd2e2025-08-20T02:08:42ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-04-011710.3389/fnagi.2025.14359961435996Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanismLin Lin0Lin Lin1Yao-Xi He2Quan Wen3Jia-Yang Liu4Yu Dai5Yu-Zhe Fei6Hang Li7Chang-Qing Li8Huan Zhou9Huan Zhou10West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, ChinaSchool of Elderly Health/Collaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Nursing, Chengdu Medical College, Chengdu, Sichuan, ChinaChengdu Eighth People’s Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, Sichuan, ChinaSchool of Nursing, Chengdu Medical College, Chengdu, Sichuan, ChinaChengdu Eighth People’s Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, Sichuan, ChinaChengdu Eighth People’s Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, Sichuan, ChinaChengdu Eighth People’s Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, Sichuan, ChinaChengdu Eighth People’s Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, Sichuan, ChinaWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, ChinaHealthy Aging Research Center, West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, ChinaIntroductionStudies have revealed that Tai Chi can enhance cognitive functions among patients with mild cognitive impairment (MCI). However, the precise mechanisms underlying this improvement remain elusive.MethodsConsequently, we conducted a study involving 54 elderly inpatients with MCI residing in a combined medical and elderly care facility in Chengdu, who were randomly divided into three groups: a control group engaging in daily living activities, a Tai Chi group that performed Tai Chi exercises in addition to control group activities, and a walking group that undertook walking activities as a supplement to the control group regimen. The intervention period lasted for 24 weeks, comprising 12 weeks of exercise and an additional 12 weeks of follow-up. The Montreal Cognitive Assessment (MoCA), Trail Making Test-A (TMT-A), Auditory Verbal Learning Test (AVLT), and biochemical assessments (measuring brain-derived neurotrophic factor, BDNF, and platelet factor 4, PF4) were administered to investigate overall cognitive function, executive function, memory capacity, and changes in serum concentrations of BDNF and PF4 before, after, and during the follow-up period. Data were analyzed using IBM SPSS 26.0, with statistical methods encompassing descriptive analysis, ANOVA, rank-sum test, repeated measures ANOVA, and generalized estimating equations.ResultsOur findings indicated that after 24 weeks of intervention, the Tai Chi group exhibited improvements in cognitive function, executive function, and memory compared to the control group. This enhancement may be attributed to an increased expression of serum BDNF.DiscussionIn conclusion, our study underscores the potential of Tai Chi in ameliorating cognitive function among elderly patients with mild cognitive impairment, thereby offering significant implications for clinical prevention and treatment strategies targeting this condition.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1435996/fullTai ChiMCIBDNFcognitive functionPF4 |
| spellingShingle | Lin Lin Lin Lin Yao-Xi He Quan Wen Jia-Yang Liu Yu Dai Yu-Zhe Fei Hang Li Chang-Qing Li Huan Zhou Huan Zhou Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism Frontiers in Aging Neuroscience Tai Chi MCI BDNF cognitive function PF4 |
| title | Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism |
| title_full | Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism |
| title_fullStr | Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism |
| title_full_unstemmed | Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism |
| title_short | Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism |
| title_sort | evaluation of the efficacy of tai chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism |
| topic | Tai Chi MCI BDNF cognitive function PF4 |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1435996/full |
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