Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates

Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates

Background: Glioblastoma (GBM) remains a significant challenge in oncology due to its resistance to standard treatments including temozolomide. This study aimed to develop and validate an integrated model for predicting GBM sensitivity to alternative chemotherapeutics and identifying new drugs and c...

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Bibliographic Details
Main Authors: Nazareno Gonzalez, Melanie Pérez Küper, Matías Garcia Fallit, Jorge A. Peña Agudelo, Alejandro Nicola Candia, Maicol Suarez Velandia, Ana Clara Romero, Guillermo Videla Richardson, Marianela Candolfi
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Brain Sciences
Subjects:
glioblastoma
drug repurposing
blood-brain barrier
Daporinad
predictive modeling
NAMPT inhibitor
Online Access:https://www.mdpi.com/2076-3425/15/6/637
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