Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus
The arcuate nucleus of the hypothalamus is arguably the most important nucleus for regulating energy homeostasis and metabolism. Since its initial description in the human brain, its function in metabolic regulation has been studied extensively. Key neuronal populations such as agouti-related peptid...
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| Format: | Article |
| Language: | English |
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Korean Society for the Study of Obesity
2025-07-01
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| Series: | Journal of Obesity & Metabolic Syndrome |
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| Online Access: | http://www.jomes.org/journal/view.html?doi=10.7570/jomes25059 |
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| author | Yu Fu |
| author_facet | Yu Fu |
| author_sort | Yu Fu |
| collection | DOAJ |
| description | The arcuate nucleus of the hypothalamus is arguably the most important nucleus for regulating energy homeostasis and metabolism. Since its initial description in the human brain, its function in metabolic regulation has been studied extensively. Key neuronal populations such as agouti-related peptide and pro-opiomelanocortin neurons have been discovered to play critical roles in feeding and body weight regulation. Recent studies have started to reveal the functional significance of other neuronal populations, especially those that promote feeding (orexigenic neurons). In this review, we discuss the history and key findings of the arcuate nucleus, with a focus on orexigenic neurons. We also highlight current challenges and knowledge gaps that remain to be addressed in future studies. |
| format | Article |
| id | doaj-art-ae1d600951544a449b291cb168da2dff |
| institution | Kabale University |
| issn | 2508-6235 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Society for the Study of Obesity |
| record_format | Article |
| series | Journal of Obesity & Metabolic Syndrome |
| spelling | doaj-art-ae1d600951544a449b291cb168da2dff2025-08-20T03:56:05ZengKorean Society for the Study of ObesityJournal of Obesity & Metabolic Syndrome2508-62352025-07-0134321322310.7570/jomes25059jomes25059Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate NucleusYu Fu0Division of Neurometabolism, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), SingaporeThe arcuate nucleus of the hypothalamus is arguably the most important nucleus for regulating energy homeostasis and metabolism. Since its initial description in the human brain, its function in metabolic regulation has been studied extensively. Key neuronal populations such as agouti-related peptide and pro-opiomelanocortin neurons have been discovered to play critical roles in feeding and body weight regulation. Recent studies have started to reveal the functional significance of other neuronal populations, especially those that promote feeding (orexigenic neurons). In this review, we discuss the history and key findings of the arcuate nucleus, with a focus on orexigenic neurons. We also highlight current challenges and knowledge gaps that remain to be addressed in future studies.http://www.jomes.org/journal/view.html?doi=10.7570/jomes25059hypothalamusarcuateagouti related neuropeptidefeedingbody weight |
| spellingShingle | Yu Fu Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus Journal of Obesity & Metabolic Syndrome hypothalamus arcuate agouti related neuropeptide feeding body weight |
| title | Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus |
| title_full | Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus |
| title_fullStr | Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus |
| title_full_unstemmed | Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus |
| title_short | Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus |
| title_sort | regulation of feeding behavior and body weight by orexigenic neurons in the arcuate nucleus |
| topic | hypothalamus arcuate agouti related neuropeptide feeding body weight |
| url | http://www.jomes.org/journal/view.html?doi=10.7570/jomes25059 |
| work_keys_str_mv | AT yufu regulationoffeedingbehaviorandbodyweightbyorexigenicneuronsinthearcuatenucleus |