Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males
Abstract Testosterone deficiency can cause abnormal lipid metabolism in men, leading to hyperlipidemia. We identified the testosterone-degrading bacterium Pseudomonas nitroreducens in the fecal samples of male patients with hyperlipidemia. Gastric administration of P. nitroreducens in mice led to te...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-024-00599-1 |
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| _version_ | 1850062156738854912 |
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| author | Jun Tao Wen Dai Yongnan Lyu Hang Liu Juan Le Ting Sun Qian Yao Zhiming Zhao Xuejun Jiang Yan Li |
| author_facet | Jun Tao Wen Dai Yongnan Lyu Hang Liu Juan Le Ting Sun Qian Yao Zhiming Zhao Xuejun Jiang Yan Li |
| author_sort | Jun Tao |
| collection | DOAJ |
| description | Abstract Testosterone deficiency can cause abnormal lipid metabolism in men, leading to hyperlipidemia. We identified the testosterone-degrading bacterium Pseudomonas nitroreducens in the fecal samples of male patients with hyperlipidemia. Gastric administration of P. nitroreducens in mice led to testosterone deficiency and elevated blood lipid levels. Whole-genome sequencing of P. nitroreducens revealed the presence of 3/17β-hydroxysteroid dehydrogenase (3/17β-HSD), a gene responsible for testosterone degradation, which is also associated with hyperlipidemia. Microbiota analysis of fecal samples collected from 158 patients with hyperlipidemia and 151 controls revealed that the relative abundance of P. nitroreducens and 3/17β-HSD in the fecal samples of patients with hyperlipidemia was significantly higher than that in controls. These results suggest that P. nitroreducens and 3/17β-HSD may be related to the onset of testosterone deficiency-induced hyperlipidemia. Therefore, treatments targeted at eradicating testosterone-degrading bacteria are a potential future option for patients with testosterone-induced hyperlipidemia and should thus be studied further. |
| format | Article |
| id | doaj-art-ae11b8a7e8394b9e868072bfae99131b |
| institution | DOAJ |
| issn | 2055-5008 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-ae11b8a7e8394b9e868072bfae99131b2025-08-20T02:50:00ZengNature Portfolionpj Biofilms and Microbiomes2055-50082024-11-0110111010.1038/s41522-024-00599-1Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in malesJun Tao0Wen Dai1Yongnan Lyu2Hang Liu3Juan Le4Ting Sun5Qian Yao6Zhiming Zhao7Xuejun Jiang8Yan Li9Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan UniversityDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan UniversityDepartment of Geratology, Renmin Hospital of Wuhan UniversityDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan UniversityAbstract Testosterone deficiency can cause abnormal lipid metabolism in men, leading to hyperlipidemia. We identified the testosterone-degrading bacterium Pseudomonas nitroreducens in the fecal samples of male patients with hyperlipidemia. Gastric administration of P. nitroreducens in mice led to testosterone deficiency and elevated blood lipid levels. Whole-genome sequencing of P. nitroreducens revealed the presence of 3/17β-hydroxysteroid dehydrogenase (3/17β-HSD), a gene responsible for testosterone degradation, which is also associated with hyperlipidemia. Microbiota analysis of fecal samples collected from 158 patients with hyperlipidemia and 151 controls revealed that the relative abundance of P. nitroreducens and 3/17β-HSD in the fecal samples of patients with hyperlipidemia was significantly higher than that in controls. These results suggest that P. nitroreducens and 3/17β-HSD may be related to the onset of testosterone deficiency-induced hyperlipidemia. Therefore, treatments targeted at eradicating testosterone-degrading bacteria are a potential future option for patients with testosterone-induced hyperlipidemia and should thus be studied further.https://doi.org/10.1038/s41522-024-00599-1 |
| spellingShingle | Jun Tao Wen Dai Yongnan Lyu Hang Liu Juan Le Ting Sun Qian Yao Zhiming Zhao Xuejun Jiang Yan Li Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males npj Biofilms and Microbiomes |
| title | Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males |
| title_full | Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males |
| title_fullStr | Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males |
| title_full_unstemmed | Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males |
| title_short | Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males |
| title_sort | role of intestinal testosterone degrading bacteria and 3 17β hsd in the pathogenesis of testosterone deficiency induced hyperlipidemia in males |
| url | https://doi.org/10.1038/s41522-024-00599-1 |
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