Prediction of hemolytic peptides and their hemolytic concentration
Abstract Peptide-based drugs often fail in clinical trials due to their toxicity or hemolytic activity against red blood cells (RBCs). Existing methods predict hemolytic peptides but not the concentration (HC50) required to lyse 50% of RBCs. This study develops classification and regression models t...
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Main Authors: | Anand Singh Rathore, Nishant Kumar, Shubham Choudhury, Naman Kumar Mehta, Gajendra P. S. Raghava |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-02-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-025-07615-w |
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