Potential applications and mechanisms of natural products in mucosal-related diseases
The mucosal barrier serves as a crucial defense against external pathogens and allergens, being widely distributed across the respiratory, gastrointestinal, urogenital tracts, and oral cavity. Its disruption can lead to various diseases, including inflammatory bowel disease, asthma, urinary tract in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1594224/full |
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| author | Wang Lin Wang Lin Xie Ruishi Xie Ruishi Xu Caijiao Xu Caijiao Luo Haoming Luo Haoming Hua Xuefeng Yao Jiyou Lu Minqiang Zhou Shuo Zhou Shuo Zhu Ming Zhu Ming Li Dongyang Li Dongyang Fang Xiaoxue Fang Xiaoxue |
| author_facet | Wang Lin Wang Lin Xie Ruishi Xie Ruishi Xu Caijiao Xu Caijiao Luo Haoming Luo Haoming Hua Xuefeng Yao Jiyou Lu Minqiang Zhou Shuo Zhou Shuo Zhu Ming Zhu Ming Li Dongyang Li Dongyang Fang Xiaoxue Fang Xiaoxue |
| author_sort | Wang Lin |
| collection | DOAJ |
| description | The mucosal barrier serves as a crucial defense against external pathogens and allergens, being widely distributed across the respiratory, gastrointestinal, urogenital tracts, and oral cavity. Its disruption can lead to various diseases, including inflammatory bowel disease, asthma, urinary tract infections, and oral inflammation. Current mainstream treatments for mucosa-associated diseases primarily involve glucocorticoids and immunosuppressants, but their long-term use may cause adverse effects. Therefore, the development of safer and more effective therapeutic strategies has become a focus of research. Natural products, with their multi-target and multi-system regulatory advantages, offer a promising avenue for the treatment of mucosal diseases. This review summarizes the potential applications of natural products in diseases of mucosal barrier dysfunction through mechanisms such as immune modulation, inflammation inhibition, tight junction protein restoration, and gut microbiota regulation, with the aim of providing insights for the exploration of novel therapeutic strategies. |
| format | Article |
| id | doaj-art-ae0b595df35b417394eba0382a805cf2 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ae0b595df35b417394eba0382a805cf22025-08-20T02:28:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15942241594224Potential applications and mechanisms of natural products in mucosal-related diseasesWang Lin0Wang Lin1Xie Ruishi2Xie Ruishi3Xu Caijiao4Xu Caijiao5Luo Haoming6Luo Haoming7Hua Xuefeng8Yao Jiyou9Lu Minqiang10Zhou Shuo11Zhou Shuo12Zhu Ming13Zhu Ming14Li Dongyang15Li Dongyang16Fang Xiaoxue17Fang Xiaoxue18Changchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaChangchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaChangchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaChangchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaThe First People’s Hospital of Guangzhou, Department of Hepatobiliary and Pancreatic Surgery, Guangzhou, ChinaThe First People’s Hospital of Guangzhou, Department of Hepatobiliary and Pancreatic Surgery, Guangzhou, ChinaThe First People’s Hospital of Guangzhou, Department of Hepatobiliary and Pancreatic Surgery, Guangzhou, ChinaChangchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaChangchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaChangchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaChangchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaThe mucosal barrier serves as a crucial defense against external pathogens and allergens, being widely distributed across the respiratory, gastrointestinal, urogenital tracts, and oral cavity. Its disruption can lead to various diseases, including inflammatory bowel disease, asthma, urinary tract infections, and oral inflammation. Current mainstream treatments for mucosa-associated diseases primarily involve glucocorticoids and immunosuppressants, but their long-term use may cause adverse effects. Therefore, the development of safer and more effective therapeutic strategies has become a focus of research. Natural products, with their multi-target and multi-system regulatory advantages, offer a promising avenue for the treatment of mucosal diseases. This review summarizes the potential applications of natural products in diseases of mucosal barrier dysfunction through mechanisms such as immune modulation, inflammation inhibition, tight junction protein restoration, and gut microbiota regulation, with the aim of providing insights for the exploration of novel therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1594224/fullmucous barriernatural productsimmune regulationinflammation inhibitiongut microbiota modulation |
| spellingShingle | Wang Lin Wang Lin Xie Ruishi Xie Ruishi Xu Caijiao Xu Caijiao Luo Haoming Luo Haoming Hua Xuefeng Yao Jiyou Lu Minqiang Zhou Shuo Zhou Shuo Zhu Ming Zhu Ming Li Dongyang Li Dongyang Fang Xiaoxue Fang Xiaoxue Potential applications and mechanisms of natural products in mucosal-related diseases Frontiers in Immunology mucous barrier natural products immune regulation inflammation inhibition gut microbiota modulation |
| title | Potential applications and mechanisms of natural products in mucosal-related diseases |
| title_full | Potential applications and mechanisms of natural products in mucosal-related diseases |
| title_fullStr | Potential applications and mechanisms of natural products in mucosal-related diseases |
| title_full_unstemmed | Potential applications and mechanisms of natural products in mucosal-related diseases |
| title_short | Potential applications and mechanisms of natural products in mucosal-related diseases |
| title_sort | potential applications and mechanisms of natural products in mucosal related diseases |
| topic | mucous barrier natural products immune regulation inflammation inhibition gut microbiota modulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1594224/full |
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