Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy
Neurodegenerative disorders are difficult to treat because of natural barrier in the brain. Moreover, neurovascular units seem to be essential targets/mediators of the nervous system cytoprotective effects. Functionalized nanomaterials have gained significant prominence in the medical domain due to...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-09-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459324000477 |
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| author | Sakshi Goswami Nickolay K. Isaev Alla B. Salmina Suresh Vir Singh Rana Sergey N. Illarioshkin Yeshvandra Verma |
| author_facet | Sakshi Goswami Nickolay K. Isaev Alla B. Salmina Suresh Vir Singh Rana Sergey N. Illarioshkin Yeshvandra Verma |
| author_sort | Sakshi Goswami |
| collection | DOAJ |
| description | Neurodegenerative disorders are difficult to treat because of natural barrier in the brain. Moreover, neurovascular units seem to be essential targets/mediators of the nervous system cytoprotective effects. Functionalized nanomaterials have gained significant prominence in the medical domain due to their extensive utilization in targeted drug delivery and therapeutics within the neurovascular system. Their remarkable potential in neurovascular therapy has been demonstrated, highlighting their effectiveness in this field. A systematic summary of the specific applications and limitations of functionalized nanomaterials in the targeted delivery system is essential for developing smart therapies to overcome the gaps in neurovascular therapy for the treatment of neurological disorders. The objective of present article was to highlight the advancements in recent therapies support the potential role of functionalized nanomaterials to tackle the difficulties in targeted delivery systems for neurodegenerative disorders. We review the role of functionalized nanomaterials as therapeutics within the neurovascular units and their potential to lead to more sophisticated and smart treatment techniques despite some obstacles, given to the patients of neurological disorders, particularly when paired with multimodal drugs who are likely to benefit from cytoprotection. This review also addresses the current understanding, gaps, and issues to be resolved. |
| format | Article |
| id | doaj-art-ae0ad235d02649b4bfb4d1bb76e7941d |
| institution | OA Journals |
| issn | 2666-4593 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-ae0ad235d02649b4bfb4d1bb76e7941d2025-08-20T01:54:45ZengElsevierBrain Disorders2666-45932024-09-011510016210.1016/j.dscb.2024.100162Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapySakshi Goswami0Nickolay K. Isaev1Alla B. Salmina2Suresh Vir Singh Rana3Sergey N. Illarioshkin4Yeshvandra Verma5Laboratory of Toxicology, Department of Toxicology, Chaudhary Charan Singh University, Meerut-250004, IndiaBrain Science Institute, Research Center of Neurology, 80, Volokolamskoe highway, 125367, Moscow, Russian Federation; M.V.Lomonosov Moscow State University, Biological Faculty, 119234 Moscow, Russian FederationBrain Science Institute, Research Center of Neurology, 80, Volokolamskoe highway, 125367, Moscow, Russian Federation; Research Institute of Molecular Medicine & Pathobiochemistry, Prof.V.F.Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russian FederationLaboratory of Toxicology, Department of Toxicology, Chaudhary Charan Singh University, Meerut-250004, IndiaBrain Science Institute, Research Center of Neurology, 80, Volokolamskoe highway, 125367, Moscow, Russian FederationLaboratory of Toxicology, Department of Toxicology, Chaudhary Charan Singh University, Meerut-250004, India; Corresponding author.Neurodegenerative disorders are difficult to treat because of natural barrier in the brain. Moreover, neurovascular units seem to be essential targets/mediators of the nervous system cytoprotective effects. Functionalized nanomaterials have gained significant prominence in the medical domain due to their extensive utilization in targeted drug delivery and therapeutics within the neurovascular system. Their remarkable potential in neurovascular therapy has been demonstrated, highlighting their effectiveness in this field. A systematic summary of the specific applications and limitations of functionalized nanomaterials in the targeted delivery system is essential for developing smart therapies to overcome the gaps in neurovascular therapy for the treatment of neurological disorders. The objective of present article was to highlight the advancements in recent therapies support the potential role of functionalized nanomaterials to tackle the difficulties in targeted delivery systems for neurodegenerative disorders. We review the role of functionalized nanomaterials as therapeutics within the neurovascular units and their potential to lead to more sophisticated and smart treatment techniques despite some obstacles, given to the patients of neurological disorders, particularly when paired with multimodal drugs who are likely to benefit from cytoprotection. This review also addresses the current understanding, gaps, and issues to be resolved.http://www.sciencedirect.com/science/article/pii/S2666459324000477CytoprotectionNeurovascular unitsFunctionalized nanomaterialsNeurodegenerative disordersBlood-brain barrier |
| spellingShingle | Sakshi Goswami Nickolay K. Isaev Alla B. Salmina Suresh Vir Singh Rana Sergey N. Illarioshkin Yeshvandra Verma Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy Brain Disorders Cytoprotection Neurovascular units Functionalized nanomaterials Neurodegenerative disorders Blood-brain barrier |
| title | Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy |
| title_full | Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy |
| title_fullStr | Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy |
| title_full_unstemmed | Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy |
| title_short | Recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy |
| title_sort | recent developments in selective therapeutic targeting of functionalized nanomaterials to neurovascular units in overcoming the gaps in neurovascular therapy |
| topic | Cytoprotection Neurovascular units Functionalized nanomaterials Neurodegenerative disorders Blood-brain barrier |
| url | http://www.sciencedirect.com/science/article/pii/S2666459324000477 |
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