Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening

Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening

Proteolysis-targeting chimeras (PROTACs) enable the selective and sub-stoichiometric elimination of pathological proteins, yet only two E3 ligases are routinely used for this purpose. Here, we expand the repertoire of PROTAC-compatible E3 ligases by identifying a novel small molecule scaffold target...

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Bibliographic Details
Main Authors: Han Zhou, Tonglian Zhou, Wenli Yu, Liping Liu, Yeonjin Ko, Kristen A Johnson, Ian A Wilson, Peter G Schultz, Michael J Bollong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
KLHDC2
PROTAC
E3 ligase
high-throughput screening
Online Access:https://elifesciences.org/articles/106844
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