Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study
IntroductionThe prognostic impact of human leukocyte antigen-E (HLA-E) expression and the proportion of natural killer (NK) cells in esophageal squamous cell carcinoma (ESCC) was investigated.MethodsThis study retrospectively evaluated 397 ESCC patients across two centers. The cumulative incidence o...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1517968/full |
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| author | Shao-jun Xu Shao-jun Xu Shao-jun Xu Yun-fan Luo Yun-fan Luo Yun-fan Luo Jin Huang Jin Huang Jin Huang Jia-hua Tu Chao Chen Chao Chen Chao Chen Yan-ming Shen Yan-ming Shen Yan-ming Shen Zhao-min Sun Zhao-min Sun Zhao-min Sun Shu-chen Chen Shu-chen Chen Shu-chen Chen |
| author_facet | Shao-jun Xu Shao-jun Xu Shao-jun Xu Yun-fan Luo Yun-fan Luo Yun-fan Luo Jin Huang Jin Huang Jin Huang Jia-hua Tu Chao Chen Chao Chen Chao Chen Yan-ming Shen Yan-ming Shen Yan-ming Shen Zhao-min Sun Zhao-min Sun Zhao-min Sun Shu-chen Chen Shu-chen Chen Shu-chen Chen |
| author_sort | Shao-jun Xu |
| collection | DOAJ |
| description | IntroductionThe prognostic impact of human leukocyte antigen-E (HLA-E) expression and the proportion of natural killer (NK) cells in esophageal squamous cell carcinoma (ESCC) was investigated.MethodsThis study retrospectively evaluated 397 ESCC patients across two centers. The cumulative incidence of recurrence (CIR) and the incidence of tumor-related death (CID) were analyzed in various groups. An immunosuppression score (ISS) was developed based on HLA-E expression and NK cell proportion. Differences between groups were adjusted using inverse probability treatment weighting (IPTW). The factors influencing cancer-specific survival (CSS) and recurrence-free survival (RFS) were also examined.ResultsPatients with low HLA-E expression had significantly higher five-year CIR and CID compared to those with high expression (CIR: 20.7% vs. 45.1%, CID: 19.3% vs. 40.1%; p< 0.001). Similarly, NK cell-positive patients had significantly better five-year CIR and CID than NK cell-negative patients (CIR: 16.3% vs. 59.6%, CID: 13.9% vs. 53.7%; p < 0.001). The Sankey diagram indicated that the low ISS group had a lower recurrence and tumor-related mortality rate (p < 0.05). After IPTW adjustment, the low ISS group showed improved five-year RFS (80.1% vs. 35.4%, p < 0.001) and five-year CSS (82.3% vs. 42.5%, p < 0.001) compared to the high ISS group.ConclusionsESCC with different ISS statuses represents two distinct biological subtypes, underscoring the need for personalized treatment strategies tailored to varying tumor behaviors. |
| format | Article |
| id | doaj-art-adfca96c13384ecba18f6c3d7e3440cc |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Frontiers in Immunology |
| spelling | doaj-art-adfca96c13384ecba18f6c3d7e3440cc2025-01-07T06:40:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15179681517968Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter studyShao-jun Xu0Shao-jun Xu1Shao-jun Xu2Yun-fan Luo3Yun-fan Luo4Yun-fan Luo5Jin Huang6Jin Huang7Jin Huang8Jia-hua Tu9Chao Chen10Chao Chen11Chao Chen12Yan-ming Shen13Yan-ming Shen14Yan-ming Shen15Zhao-min Sun16Zhao-min Sun17Zhao-min Sun18Shu-chen Chen19Shu-chen Chen20Shu-chen Chen21Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, ChinaKey Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, ChinaKey Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, ChinaKey Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, The First Hospital of Putian, Putian, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, ChinaKey Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, ChinaKey Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, ChinaKey Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, ChinaKey Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, ChinaIntroductionThe prognostic impact of human leukocyte antigen-E (HLA-E) expression and the proportion of natural killer (NK) cells in esophageal squamous cell carcinoma (ESCC) was investigated.MethodsThis study retrospectively evaluated 397 ESCC patients across two centers. The cumulative incidence of recurrence (CIR) and the incidence of tumor-related death (CID) were analyzed in various groups. An immunosuppression score (ISS) was developed based on HLA-E expression and NK cell proportion. Differences between groups were adjusted using inverse probability treatment weighting (IPTW). The factors influencing cancer-specific survival (CSS) and recurrence-free survival (RFS) were also examined.ResultsPatients with low HLA-E expression had significantly higher five-year CIR and CID compared to those with high expression (CIR: 20.7% vs. 45.1%, CID: 19.3% vs. 40.1%; p< 0.001). Similarly, NK cell-positive patients had significantly better five-year CIR and CID than NK cell-negative patients (CIR: 16.3% vs. 59.6%, CID: 13.9% vs. 53.7%; p < 0.001). The Sankey diagram indicated that the low ISS group had a lower recurrence and tumor-related mortality rate (p < 0.05). After IPTW adjustment, the low ISS group showed improved five-year RFS (80.1% vs. 35.4%, p < 0.001) and five-year CSS (82.3% vs. 42.5%, p < 0.001) compared to the high ISS group.ConclusionsESCC with different ISS statuses represents two distinct biological subtypes, underscoring the need for personalized treatment strategies tailored to varying tumor behaviors.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1517968/fullesophageal squamous cell carcinoma (ESCC)human leukocyte antigen-E (HLA-E)natural killer (NK) cellsinverse probability treatment weighting (IPTW)prognosis |
| spellingShingle | Shao-jun Xu Shao-jun Xu Shao-jun Xu Yun-fan Luo Yun-fan Luo Yun-fan Luo Jin Huang Jin Huang Jin Huang Jia-hua Tu Chao Chen Chao Chen Chao Chen Yan-ming Shen Yan-ming Shen Yan-ming Shen Zhao-min Sun Zhao-min Sun Zhao-min Sun Shu-chen Chen Shu-chen Chen Shu-chen Chen Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study Frontiers in Immunology esophageal squamous cell carcinoma (ESCC) human leukocyte antigen-E (HLA-E) natural killer (NK) cells inverse probability treatment weighting (IPTW) prognosis |
| title | Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study |
| title_full | Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study |
| title_fullStr | Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study |
| title_full_unstemmed | Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study |
| title_short | Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study |
| title_sort | prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma a multicenter study |
| topic | esophageal squamous cell carcinoma (ESCC) human leukocyte antigen-E (HLA-E) natural killer (NK) cells inverse probability treatment weighting (IPTW) prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1517968/full |
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