XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy
Immune checkpoint inhibitors have a poor effect in treating ovarian cancer, and the specific mechanism is unknown. The purpose of this research was to investigate the impact of XPR1 on controlling autophagy in ovarian cancer. The findings suggested an increase in XPR1 expression in ovarian cancer ti...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304224003040 |
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| author | Hui Wang Xiaodong Luo Bo Yang Furong Tang Xingwei Jiang Hongtao Zhu Jianguo Hu |
| author_facet | Hui Wang Xiaodong Luo Bo Yang Furong Tang Xingwei Jiang Hongtao Zhu Jianguo Hu |
| author_sort | Hui Wang |
| collection | DOAJ |
| description | Immune checkpoint inhibitors have a poor effect in treating ovarian cancer, and the specific mechanism is unknown. The purpose of this research was to investigate the impact of XPR1 on controlling autophagy in ovarian cancer. The findings suggested an increase in XPR1 expression in ovarian cancer tissues. The elevated level of its expression was linked to the stage of ovarian cancer, as well as overall survival and progression-free survival. XPR1 enhanced the growth and spread of ovarian cancer while suppressing autophagy. Moreover, XPR1 suppressed autophagy flux by interacting with LAMP1 and the PI3K/Akt/mTOR pathway. XPR1 controlled the positioning and production of MHC-I molecules on the surfaces of ovarian cancer cells via autophagy. Silencing XPR1 combined with the autophagy inhibitor chloroquine significantly inhibited tumor growth in mouse ovarian cancer models. In conclusion, the findings indicate that XPR1 could serve as a promising target for the diagnosis and treatment of ovarian cancer. Combined autophagy inhibitors may improve the sensitivity of ovarian cancer immunotherapy. |
| format | Article |
| id | doaj-art-adfa44b83f9a484da264b83aaae38c82 |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-adfa44b83f9a484da264b83aaae38c822025-08-20T03:30:37ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-09-0112510150710.1016/j.gendis.2024.101507XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagyHui Wang0Xiaodong Luo1Bo Yang2Furong Tang3Xingwei Jiang4Hongtao Zhu5Jianguo Hu6Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, ChinaDepartment of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, ChinaDepartment of Obstetrics and Gynecology, Chongqing Xiushan People's Hospital, Xiushan Tujia and Miao Autonomous County, Chongqing 409900, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan 610000, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan 610000, ChinaDepartment of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, ChinaDepartment of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, ChinaDepartment of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China; Corresponding author.Immune checkpoint inhibitors have a poor effect in treating ovarian cancer, and the specific mechanism is unknown. The purpose of this research was to investigate the impact of XPR1 on controlling autophagy in ovarian cancer. The findings suggested an increase in XPR1 expression in ovarian cancer tissues. The elevated level of its expression was linked to the stage of ovarian cancer, as well as overall survival and progression-free survival. XPR1 enhanced the growth and spread of ovarian cancer while suppressing autophagy. Moreover, XPR1 suppressed autophagy flux by interacting with LAMP1 and the PI3K/Akt/mTOR pathway. XPR1 controlled the positioning and production of MHC-I molecules on the surfaces of ovarian cancer cells via autophagy. Silencing XPR1 combined with the autophagy inhibitor chloroquine significantly inhibited tumor growth in mouse ovarian cancer models. In conclusion, the findings indicate that XPR1 could serve as a promising target for the diagnosis and treatment of ovarian cancer. Combined autophagy inhibitors may improve the sensitivity of ovarian cancer immunotherapy.http://www.sciencedirect.com/science/article/pii/S2352304224003040AutophagyLAMP1MHC-1Ovarian cancerXPR1 |
| spellingShingle | Hui Wang Xiaodong Luo Bo Yang Furong Tang Xingwei Jiang Hongtao Zhu Jianguo Hu XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy Genes and Diseases Autophagy LAMP1 MHC-1 Ovarian cancer XPR1 |
| title | XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy |
| title_full | XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy |
| title_fullStr | XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy |
| title_full_unstemmed | XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy |
| title_short | XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy |
| title_sort | xpr1 promotes ovarian cancer growth and regulates mhc i through autophagy |
| topic | Autophagy LAMP1 MHC-1 Ovarian cancer XPR1 |
| url | http://www.sciencedirect.com/science/article/pii/S2352304224003040 |
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