A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection against Group B Streptococcus Infections in Adult Susceptible Mice.

A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection against Group B Streptococcus Infections in Adult Susceptible Mice.

Group B Streptococcus (GBS), a commensal organism, can turn into a life-threatening pathogen in neonates and elderly, or in adults with severe underlying diseases such as diabetes. We developed a vaccine targeting the GBS glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme detected...

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Main Authors: Joana Alves, Pedro Madureira, Maria Teresa Baltazar, Leandro Barros, Liliana Oliveira, Ricardo Jorge Dinis-Oliveira, Elva Bonifácio Andrade, Adília Ribeiro, Luís Mira Vieira, Patrick Trieu-Cuot, José Alberto Duarte, Félix Carvalho, Paula Ferreira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144196&type=printable
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