Disulfiram induces redox imbalance and perturbations in central glucose catabolism and metal homeostasis to inhibit the growth of Staphylococcus aureus

Disulfiram induces redox imbalance and perturbations in central glucose catabolism and metal homeostasis to inhibit the growth of Staphylococcus aureus

Abstract Disulfiram (Antabuse®) is a prescription alcohol sobriety aid that has shown repurposing potential as an antibacterial drug for infections due to Gram-positive bacteria. In this investigation, we sought to define the principal mechanisms that disulfiram operates as a growth inhibitor of Sta...

Full description

Saved in:
Bibliographic Details
Main Authors: Timothy E. Long, Surya Teja Naidu, Emily G. Hissom, Yogesh Meka, Hasitha Chavva, Kathleen C. Brown, Meagan E. Valentine, Jun Fan, James Denvir, Donald A. Primerano, Hongwei D. Yu, Monica A. Valentovic
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-00078-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-00078-3

Similar Items