Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis
Leukapheresis is a treatment used to reduce leukocytes to decrease the number of white blood cells in circulation and prevent the risks of hyperviscosity and cerebrovascular and pulmonary leukostasis. We present a case of pro-B-cell acute lymphoblastic leukemia (ALL) with hyperleukocytosis in a 6-mo...
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| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1497943/full |
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| author | Shuang Bian Nannan Li Hui Gao |
| author_facet | Shuang Bian Nannan Li Hui Gao |
| author_sort | Shuang Bian |
| collection | DOAJ |
| description | Leukapheresis is a treatment used to reduce leukocytes to decrease the number of white blood cells in circulation and prevent the risks of hyperviscosity and cerebrovascular and pulmonary leukostasis. We present a case of pro-B-cell acute lymphoblastic leukemia (ALL) with hyperleukocytosis in a 6-month-old infant, characterized by a positive KMT2A/AFF1 fusion gene with a leukocyte count of 1,755 × 109/L. After two consecutive sessions of leukapheresis, the white blood cell count decreased to 55 × 109/L. The infant recovered after the high-dose methotrexate chemotherapy. These results demonstrate that leukapheresis is a feasible treatment option for acute hyperleukocytic leukemia in infants with ALL. |
| format | Article |
| id | doaj-art-ade2c00d17d74f4ea547682eecae4b5a |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-ade2c00d17d74f4ea547682eecae4b5a2025-08-20T02:30:39ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-12-011210.3389/fped.2024.14979431497943Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresisShuang BianNannan LiHui GaoLeukapheresis is a treatment used to reduce leukocytes to decrease the number of white blood cells in circulation and prevent the risks of hyperviscosity and cerebrovascular and pulmonary leukostasis. We present a case of pro-B-cell acute lymphoblastic leukemia (ALL) with hyperleukocytosis in a 6-month-old infant, characterized by a positive KMT2A/AFF1 fusion gene with a leukocyte count of 1,755 × 109/L. After two consecutive sessions of leukapheresis, the white blood cell count decreased to 55 × 109/L. The infant recovered after the high-dose methotrexate chemotherapy. These results demonstrate that leukapheresis is a feasible treatment option for acute hyperleukocytic leukemia in infants with ALL.https://www.frontiersin.org/articles/10.3389/fped.2024.1497943/fullleukapheresisacute hyperleukocytic leukemiainfantacute lymphoblastic leukemiawhite blood cells |
| spellingShingle | Shuang Bian Nannan Li Hui Gao Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis Frontiers in Pediatrics leukapheresis acute hyperleukocytic leukemia infant acute lymphoblastic leukemia white blood cells |
| title | Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis |
| title_full | Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis |
| title_fullStr | Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis |
| title_full_unstemmed | Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis |
| title_short | Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis |
| title_sort | case report a case of infantile acute hyperleukocytic leukemia treated by leukapheresis |
| topic | leukapheresis acute hyperleukocytic leukemia infant acute lymphoblastic leukemia white blood cells |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1497943/full |
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