Mechanism of action of decitabine in treating acute lymphoblastic leukemia

Mechanism of action of decitabine in treating acute lymphoblastic leukemia

PurposeThis study aimed to evaluate the underlying mechanisms of decitabine (DAC) in inhibiting acute T-acute lymphoblastic leukemia (T-ALL) cell proliferation and promoting apoptosis.MethodsHuman T-ALL cells (CCRF-CEM) were treated with varying concentrations of DAC, and cell proliferation was asse...

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Bibliographic Details
Main Authors: Xiaohui Gao, Hui Zeng, Fei Sun, Xiaoyan Zhao, Haibing Wu, Minchao Yan, Yuan Li, Qinyan Fu, Gang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Medicine
Subjects:
decitabine
acute lymphoblastic leukemia
PTEN
4EBP1
tumor growth
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1614592/full
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