Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway

Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway

Abstract Background Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). WRN is known to protect somatic cells including adult stem cells from premature senescence. Loss of WRN in mesenchymal stem cells (MSCs) not only drives the cells to premature...

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Bibliographic Details
Main Authors: Hei-Yin Tam, Jiaxing Liu, Tsz-Ching Yiu, Adrian On-Wah Leung, Chang Li, Shen Gu, Owen Rennert, Boxian Huang, Hoi-Hung Cheung
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell & Bioscience
Subjects:
Werner syndrome
AKT signaling
SHIP
Senescence
WRN
Mesenchymal stem cell
Online Access:https://doi.org/10.1186/s13578-025-01355-4
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