Modeling the Influence of <i>CYP2C9</i> and <i>ABCB1</i> Gene Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Losartan

Modeling the Influence of <i>CYP2C9</i> and <i>ABCB1</i> Gene Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Losartan

<b>Background/Objectives:</b> Hypertension is a pathological condition characterized by elevated systolic and/or diastolic blood pressure. A range of pharmacotherapeutic agents are available to treat this condition and prevent complications, including the angiotensin II AT1-receptor bloc...

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Bibliographic Details
Main Authors: Dmitry Babaev, Elena Kutumova, Fedor Kolpakov
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceutics
Subjects:
arterial hypertension
losartan
pharmacokinetics
pharmacodynamics
<i>ABCB1</i>
<i>CYP2C9</i>
Online Access:https://www.mdpi.com/1999-4923/17/7/935
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