QSP modeling of loncastuximab tesirine with T-cell-dependent bispecific antibodies guides dose-regimen strategy

QSP modeling of loncastuximab tesirine with T-cell-dependent bispecific antibodies guides dose-regimen strategy

Abstract Antibody-drug conjugates (ADCs) and T-cell-dependent bispecific antibodies (TDBs) show single-agent efficacy in relapsed/refractory (R/R) lymphomas. While coadministering therapeutics with orthogonal mechanisms of action may safely enhance efficacy, testing every potential combination regim...

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Bibliographic Details
Main Authors: Yuezhe Li, A. Katharina Wilkins, Jimena Davis, Timothy Knab, Marie Toukam, Joseph P. Boni, Daniel C. Kirouac
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00544-8
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