Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysisResearch in context
Summary: Background: Intrapancreatic fat deposition is associated with increased cardiovascular risk in adults, but the association is less clear in children. Our goal in this work was therefore to conduct a systematic review and meta-analysis of the associations between intrapancreatic fat deposit...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537025001373 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850191443559186432 |
|---|---|
| author | Claudia Izquierdo Rodríguez Cristina Cadenas-Sanchez José L. Santos Jonatan R. Ruiz María Medrano Vicente Martínez-Vizcaíno Michael I. Goran Idoia Labayen |
| author_facet | Claudia Izquierdo Rodríguez Cristina Cadenas-Sanchez José L. Santos Jonatan R. Ruiz María Medrano Vicente Martínez-Vizcaíno Michael I. Goran Idoia Labayen |
| author_sort | Claudia Izquierdo Rodríguez |
| collection | DOAJ |
| description | Summary: Background: Intrapancreatic fat deposition is associated with increased cardiovascular risk in adults, but the association is less clear in children. Our goal in this work was therefore to conduct a systematic review and meta-analysis of the associations between intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents. Methods: Systematic searches were conducted in MEDLINE, Web of Science, and Scopus from database inception to January 11, 2025 (registration number: CRD42022374159). Random-effects meta-analysis was performed to obtain pooled correlations estimates of the association of intrapancreatic fat deposition with various adiposity related outcomes (i.e., overall/central adiposity and specific fat depots; primary outcome) and cardiometabolic risk factors (i.e., glycaemic traits, insulin resistance/sensitivity, insulin secretion surrogates, plasma lipids, and blood pressure; secondary outcomes). Risk of bias and the quality of evidence were evaluated. Findings: We identified a total of 252 studies, of which 15 unique studies (N = 1261 participants, mean age ranged 10.6–17.7 years, 44.4% females) were eligible for meta-analysis. Magnetic resonance imaging-measured intrapancreatic fat deposition showed a small to medium positive significant association with adiposity (n = 53 studies, r = 0.24 [95% CI:0.19; 0.29], I2 = 61.5%), impaired glycaemic traits and insulin sensitivity (n = 11 studies, r = 0.15 [95% CI:0.03; 0.26], I2 = 58.9%), and HDL levels (n = 7 studies, pooled r = 0.11 [95% CI: 0.01; 0.20], I2 = 0%), and increased blood pressure (n = 6 studies, pooled r = 0.15 [95% CI: 0.05; 0.25], I2 = 0%). Interpretation: Intrapancreatic fat deposition may increase the risk of cardiometabolic disturbances in children. Therefore, it requires more attention in clinical research as an early indicator of ectopic fat deposition, insulin resistance and metabolic syndrome. Longitudinal studies are necessary to understand the temporal dynamics of these associations and to determine the long-term impact of intrapancreatic fat deposition on the risk of developing type 2 diabetes and cardiovascular diseases. Funding: “Plan de Promoción de Grupos de investigación”, Public University of Navarre. |
| format | Article |
| id | doaj-art-adc509deecfe4026a7568b8bbac70dd8 |
| institution | OA Journals |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj-art-adc509deecfe4026a7568b8bbac70dd82025-08-20T02:14:54ZengElsevierEClinicalMedicine2589-53702025-05-018310320510.1016/j.eclinm.2025.103205Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysisResearch in contextClaudia Izquierdo Rodríguez0Cristina Cadenas-Sanchez1José L. Santos2Jonatan R. Ruiz3María Medrano4Vicente Martínez-Vizcaíno5Michael I. Goran6Idoia Labayen7Department of Health Sciences, ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Public University of Navarre, Pamplona, Spain; IdiSNA: Navarra Institute for Health Research (IdiSNA), Pamplona, SpainDepartment of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Cardiology, Stanford University, Stanford, CA, United States; Veterans Affair Palo Alto Health Care System, Palo Alto, CA, United States; Corresponding author. Department of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.Department of Health Sciences, ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Public University of Navarre, Pamplona, Spain; Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, SpainDepartment of Health Sciences, ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Public University of Navarre, Pamplona, Spain; IdiSNA: Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain; Universidad Autónoma de Chile, Facultad de Ciencias de la Salud, Talca, ChileDepartment of Pediatrics, Center for Endocrinology, Diabetes and Metabolism Los Angeles, Keck School of Medicine of USC, Children’s Hospital Los Angeles, Los Angeles, CA, United StatesDepartment of Health Sciences, ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Public University of Navarre, Pamplona, Spain; IdiSNA: Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Corresponding author. Department of Health Sciences, Public University of Navarre, Pamplona, Spain. Calle Tajonar 22, Jerónimo de Ayanz Research building, 31006, Pamplona, Spain.Summary: Background: Intrapancreatic fat deposition is associated with increased cardiovascular risk in adults, but the association is less clear in children. Our goal in this work was therefore to conduct a systematic review and meta-analysis of the associations between intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents. Methods: Systematic searches were conducted in MEDLINE, Web of Science, and Scopus from database inception to January 11, 2025 (registration number: CRD42022374159). Random-effects meta-analysis was performed to obtain pooled correlations estimates of the association of intrapancreatic fat deposition with various adiposity related outcomes (i.e., overall/central adiposity and specific fat depots; primary outcome) and cardiometabolic risk factors (i.e., glycaemic traits, insulin resistance/sensitivity, insulin secretion surrogates, plasma lipids, and blood pressure; secondary outcomes). Risk of bias and the quality of evidence were evaluated. Findings: We identified a total of 252 studies, of which 15 unique studies (N = 1261 participants, mean age ranged 10.6–17.7 years, 44.4% females) were eligible for meta-analysis. Magnetic resonance imaging-measured intrapancreatic fat deposition showed a small to medium positive significant association with adiposity (n = 53 studies, r = 0.24 [95% CI:0.19; 0.29], I2 = 61.5%), impaired glycaemic traits and insulin sensitivity (n = 11 studies, r = 0.15 [95% CI:0.03; 0.26], I2 = 58.9%), and HDL levels (n = 7 studies, pooled r = 0.11 [95% CI: 0.01; 0.20], I2 = 0%), and increased blood pressure (n = 6 studies, pooled r = 0.15 [95% CI: 0.05; 0.25], I2 = 0%). Interpretation: Intrapancreatic fat deposition may increase the risk of cardiometabolic disturbances in children. Therefore, it requires more attention in clinical research as an early indicator of ectopic fat deposition, insulin resistance and metabolic syndrome. Longitudinal studies are necessary to understand the temporal dynamics of these associations and to determine the long-term impact of intrapancreatic fat deposition on the risk of developing type 2 diabetes and cardiovascular diseases. Funding: “Plan de Promoción de Grupos de investigación”, Public University of Navarre.http://www.sciencedirect.com/science/article/pii/S2589537025001373PancreasBody mass indexFat massInsulinGlucoseLipids |
| spellingShingle | Claudia Izquierdo Rodríguez Cristina Cadenas-Sanchez José L. Santos Jonatan R. Ruiz María Medrano Vicente Martínez-Vizcaíno Michael I. Goran Idoia Labayen Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysisResearch in context EClinicalMedicine Pancreas Body mass index Fat mass Insulin Glucose Lipids |
| title | Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysisResearch in context |
| title_full | Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysisResearch in context |
| title_fullStr | Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysisResearch in context |
| title_full_unstemmed | Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysisResearch in context |
| title_short | Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysisResearch in context |
| title_sort | understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents a systematic review and meta analysisresearch in context |
| topic | Pancreas Body mass index Fat mass Insulin Glucose Lipids |
| url | http://www.sciencedirect.com/science/article/pii/S2589537025001373 |
| work_keys_str_mv | AT claudiaizquierdorodriguez understandingtheassociationofintrapancreaticfatdepositionwithadiposityandcomponentsofmetabolicsyndromeinchildrenandadolescentsasystematicreviewandmetaanalysisresearchincontext AT cristinacadenassanchez understandingtheassociationofintrapancreaticfatdepositionwithadiposityandcomponentsofmetabolicsyndromeinchildrenandadolescentsasystematicreviewandmetaanalysisresearchincontext AT joselsantos understandingtheassociationofintrapancreaticfatdepositionwithadiposityandcomponentsofmetabolicsyndromeinchildrenandadolescentsasystematicreviewandmetaanalysisresearchincontext AT jonatanrruiz understandingtheassociationofintrapancreaticfatdepositionwithadiposityandcomponentsofmetabolicsyndromeinchildrenandadolescentsasystematicreviewandmetaanalysisresearchincontext AT mariamedrano understandingtheassociationofintrapancreaticfatdepositionwithadiposityandcomponentsofmetabolicsyndromeinchildrenandadolescentsasystematicreviewandmetaanalysisresearchincontext AT vicentemartinezvizcaino understandingtheassociationofintrapancreaticfatdepositionwithadiposityandcomponentsofmetabolicsyndromeinchildrenandadolescentsasystematicreviewandmetaanalysisresearchincontext AT michaeligoran understandingtheassociationofintrapancreaticfatdepositionwithadiposityandcomponentsofmetabolicsyndromeinchildrenandadolescentsasystematicreviewandmetaanalysisresearchincontext AT idoialabayen understandingtheassociationofintrapancreaticfatdepositionwithadiposityandcomponentsofmetabolicsyndromeinchildrenandadolescentsasystematicreviewandmetaanalysisresearchincontext |