'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a Tuberculoma
Failure of tuberculosis patients to respond to treatment is usually explained by one or more of five mechanisms: improper drug prescription; patient nonadherence to prescribed therapy; primary or acquired drug resistance; drug malabsorption; and rarely, exogenous reinfection with a drug-resistant is...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2000/156183 |
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| _version_ | 1832566498199076864 |
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| author | Richard Long Sylvia Chomyc Evelina Der Daniel S Sitar |
| author_facet | Richard Long Sylvia Chomyc Evelina Der Daniel S Sitar |
| author_sort | Richard Long |
| collection | DOAJ |
| description | Failure of tuberculosis patients to respond to treatment is usually explained by one or more of five mechanisms: improper drug prescription; patient nonadherence to prescribed therapy; primary or acquired drug resistance; drug malabsorption; and rarely, exogenous reinfection with a drug-resistant isolate. Response to treatment is best measured bacteriologically; two different smear and one culture criteria for failure are widely used. Patients meeting either smear, but not culture, criteria for treatment failure may be said to have 'pseudo' treatment failure. Whether a patient can meet both smear criteria for failure, and not have a mechanism for treatment failure nor meet culture criteria, is unknown. A case of 'pseudo' treatment failure is reported in which both smear criteria for failure were met, but no mechanism for failure was proven to be operative. |
| format | Article |
| id | doaj-art-adc12d0f93394766aa519808970dd660 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-adc12d0f93394766aa519808970dd6602025-02-03T01:04:03ZengWileyCanadian Respiratory Journal1198-22412000-01-0171798310.1155/2000/156183'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a TuberculomaRichard Long0Sylvia Chomyc1Evelina Der2Daniel S Sitar3Department of Medicine and Medical Microbiology, University of Alberta, Edmonton, Alberta, CanadaDepartment of Medicine and Medical Microbiology, University of Alberta, Edmonton, Alberta, CanadaCapital HealthTuberculosis Clinic, Edmonton, Alberta, CanadaClinical Pharmacology Section, University of Manitoba, Winnipeg, Manitoba, CanadaFailure of tuberculosis patients to respond to treatment is usually explained by one or more of five mechanisms: improper drug prescription; patient nonadherence to prescribed therapy; primary or acquired drug resistance; drug malabsorption; and rarely, exogenous reinfection with a drug-resistant isolate. Response to treatment is best measured bacteriologically; two different smear and one culture criteria for failure are widely used. Patients meeting either smear, but not culture, criteria for treatment failure may be said to have 'pseudo' treatment failure. Whether a patient can meet both smear criteria for failure, and not have a mechanism for treatment failure nor meet culture criteria, is unknown. A case of 'pseudo' treatment failure is reported in which both smear criteria for failure were met, but no mechanism for failure was proven to be operative.http://dx.doi.org/10.1155/2000/156183 |
| spellingShingle | Richard Long Sylvia Chomyc Evelina Der Daniel S Sitar 'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a Tuberculoma Canadian Respiratory Journal |
| title | 'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a Tuberculoma |
| title_full | 'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a Tuberculoma |
| title_fullStr | 'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a Tuberculoma |
| title_full_unstemmed | 'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a Tuberculoma |
| title_short | 'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a Tuberculoma |
| title_sort | pseudo treatment failure of pulmonary tuberculosis in association with a tuberculoma |
| url | http://dx.doi.org/10.1155/2000/156183 |
| work_keys_str_mv | AT richardlong pseudotreatmentfailureofpulmonarytuberculosisinassociationwithatuberculoma AT sylviachomyc pseudotreatmentfailureofpulmonarytuberculosisinassociationwithatuberculoma AT evelinader pseudotreatmentfailureofpulmonarytuberculosisinassociationwithatuberculoma AT danielssitar pseudotreatmentfailureofpulmonarytuberculosisinassociationwithatuberculoma |