High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic Encephalitis
Though raised titres of voltage gated potassium channel (VGKC) complex antibodies have been occasionally associated with extracranial tumours, mainly presenting as Morvan's Syndrome or neuromyotonia, they have not yet been reported to be associated with an intracranial malignancy. This is espec...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/458790 |
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| author | Dilan Athauda R. S. Delamont E. De Pablo-Fernandez |
| author_facet | Dilan Athauda R. S. Delamont E. De Pablo-Fernandez |
| author_sort | Dilan Athauda |
| collection | DOAJ |
| description | Though raised titres of voltage gated potassium channel (VGKC) complex antibodies have been occasionally associated with extracranial tumours, mainly presenting as Morvan's Syndrome or neuromyotonia, they have not yet been reported to be associated with an intracranial malignancy. This is especially important as misdiagnosis of these conditions and delay of the appropriate treatment can have important prognostic implications. We describe a patient with a high grade glioma presenting with clinical, radiological, and serological features consistent with the diagnosis of VGKC antibody associated limbic encephalitis (LE). This is the first association between a primary brain tumour and high titre of VGKC complex antibodies. Clinicoradiological progression despite effective immunosuppressive treatment should prompt clinicians to look for alternative diagnoses. Further studies to elucidate a possible association between VGKC complex and other surface antigen antibodies with primary brain tumours should be carried out. |
| format | Article |
| id | doaj-art-adc0d75b670344baa88d59af1514180d |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-adc0d75b670344baa88d59af1514180d2025-02-03T01:01:09ZengWileyCase Reports in Neurological Medicine2090-66682090-66762014-01-01201410.1155/2014/458790458790High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic EncephalitisDilan Athauda0R. S. Delamont1E. De Pablo-Fernandez2Neurology Department, Darent Valley Hospital, Darenth Wood Road, Dartford & Gravesham NHS Trust, Dartford DA2 8DA, UKNeurology Department, Kings College Hospital, London SE5 3RS, UKNeurology Department, Darent Valley Hospital, Darenth Wood Road, Dartford & Gravesham NHS Trust, Dartford DA2 8DA, UKThough raised titres of voltage gated potassium channel (VGKC) complex antibodies have been occasionally associated with extracranial tumours, mainly presenting as Morvan's Syndrome or neuromyotonia, they have not yet been reported to be associated with an intracranial malignancy. This is especially important as misdiagnosis of these conditions and delay of the appropriate treatment can have important prognostic implications. We describe a patient with a high grade glioma presenting with clinical, radiological, and serological features consistent with the diagnosis of VGKC antibody associated limbic encephalitis (LE). This is the first association between a primary brain tumour and high titre of VGKC complex antibodies. Clinicoradiological progression despite effective immunosuppressive treatment should prompt clinicians to look for alternative diagnoses. Further studies to elucidate a possible association between VGKC complex and other surface antigen antibodies with primary brain tumours should be carried out.http://dx.doi.org/10.1155/2014/458790 |
| spellingShingle | Dilan Athauda R. S. Delamont E. De Pablo-Fernandez High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic Encephalitis Case Reports in Neurological Medicine |
| title | High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic Encephalitis |
| title_full | High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic Encephalitis |
| title_fullStr | High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic Encephalitis |
| title_full_unstemmed | High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic Encephalitis |
| title_short | High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic Encephalitis |
| title_sort | high grade glioma mimicking voltage gated potassium channel complex associated antibody limbic encephalitis |
| url | http://dx.doi.org/10.1155/2014/458790 |
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