Botulinum toxin and benign prostatic hyperplasia
Benign prostatic hyperplasia (BPH) is a clinical condition where lower urinary tract symptoms are caused by both a physically obstructing prostate as well as tight smooth muscles around the bladder outlet. Treatment of this condition with botulinum toxin has been used since 2003, but this interest h...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388217300905 |
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| author | Lay Guat Ng |
| author_facet | Lay Guat Ng |
| author_sort | Lay Guat Ng |
| collection | DOAJ |
| description | Benign prostatic hyperplasia (BPH) is a clinical condition where lower urinary tract symptoms are caused by both a physically obstructing prostate as well as tight smooth muscles around the bladder outlet. Treatment of this condition with botulinum toxin has been used since 2003, but this interest has somewhat died down after two large randomized controlled trials (RCTs) showing equivalence of results between their treatment and placebo arms. However, with review of animal studies and unexplained exaggerated effect of the placebo arms of the two RCTs, together with recent data of sustained benefits after 18 months of treatment, the place of botulinum toxin in the BPH field is probably still present. |
| format | Article |
| id | doaj-art-adbb8f9929494bb6b1d1b636f62cf967 |
| institution | OA Journals |
| issn | 2214-3882 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-adbb8f9929494bb6b1d1b636f62cf9672025-08-20T01:55:52ZengElsevierAsian Journal of Urology2214-38822018-01-0151333610.1016/j.ajur.2017.11.003Botulinum toxin and benign prostatic hyperplasiaLay Guat NgBenign prostatic hyperplasia (BPH) is a clinical condition where lower urinary tract symptoms are caused by both a physically obstructing prostate as well as tight smooth muscles around the bladder outlet. Treatment of this condition with botulinum toxin has been used since 2003, but this interest has somewhat died down after two large randomized controlled trials (RCTs) showing equivalence of results between their treatment and placebo arms. However, with review of animal studies and unexplained exaggerated effect of the placebo arms of the two RCTs, together with recent data of sustained benefits after 18 months of treatment, the place of botulinum toxin in the BPH field is probably still present.http://www.sciencedirect.com/science/article/pii/S2214388217300905Benign prostatic hyperplasiaBotulinum toxinBladder outlet obstruction |
| spellingShingle | Lay Guat Ng Botulinum toxin and benign prostatic hyperplasia Asian Journal of Urology Benign prostatic hyperplasia Botulinum toxin Bladder outlet obstruction |
| title | Botulinum toxin and benign prostatic hyperplasia |
| title_full | Botulinum toxin and benign prostatic hyperplasia |
| title_fullStr | Botulinum toxin and benign prostatic hyperplasia |
| title_full_unstemmed | Botulinum toxin and benign prostatic hyperplasia |
| title_short | Botulinum toxin and benign prostatic hyperplasia |
| title_sort | botulinum toxin and benign prostatic hyperplasia |
| topic | Benign prostatic hyperplasia Botulinum toxin Bladder outlet obstruction |
| url | http://www.sciencedirect.com/science/article/pii/S2214388217300905 |
| work_keys_str_mv | AT layguatng botulinumtoxinandbenignprostatichyperplasia |