Impact of <i>Kickxia elatine</i> In Vitro-Derived Stem Cells on the Biophysical Properties of Facial Skin: A Placebo-Controlled Trial
The growing demand for natural and sustainable skincare products has driven interest in plant-based active ingredients, especially from in vitro cultures. This placebo-controlled study investigated the impact of a facial cream containing 2% <i>Kickxia elatine</i> (L.) Dumort cell suspens...
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2025-08-01
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| author | Anastasia Aliesa Hermosaningtyas Anna Kroma-Szal Justyna Gornowicz-Porowska Maria Urbanska Anna Budzianowska Małgorzata Kikowska |
| author_facet | Anastasia Aliesa Hermosaningtyas Anna Kroma-Szal Justyna Gornowicz-Porowska Maria Urbanska Anna Budzianowska Małgorzata Kikowska |
| author_sort | Anastasia Aliesa Hermosaningtyas |
| collection | DOAJ |
| description | The growing demand for natural and sustainable skincare products has driven interest in plant-based active ingredients, especially from in vitro cultures. This placebo-controlled study investigated the impact of a facial cream containing 2% <i>Kickxia elatine</i> (L.) Dumort cell suspension culture extract on various skin biophysical parameters. The cream was applied to the cheek once daily for six weeks on 40 healthy female volunteers between the ages of 40 to 49. The evaluated skin parameters including skin hydration, transepidermal water loss (TEWL), erythema intensity (EI), melanin intensity (MI), skin surface pH, and skin structure, wrinkle depth, vascular lesions, and vascular discolouration. The results indicated that significant improvements were observed in skin hydration (from 40.36 to 63.00 AU, <i>p</i> < 0.001) and there was a decrease in TEWL score (14.82 to 11.76 g/h/m<sup>2</sup>, <i>p</i> < 0.001), while the skin surface pH was maintained (14.82 to 11.76 g/h/m<sup>2</sup>, <i>p</i> < 0.001). Moreover, the <i>K. elatine</i> cell extract significantly improved skin structure values (9.23 to 8.50, <i>p</i> = 0.028), reduced vascular lesions (2.72 to 1.54 mm<sup>2</sup>, <i>p</i> = 0.011), and lowered skin discolouration (20.98% to 14.84%, <i>p</i> < 0.001), indicating its moisturising, protective, brightening, and soothing properties. These findings support the potential use of <i>K. elatine</i> cell extract in dermocosmetic formulations targeting dry, sensitive, or ageing skin. |
| format | Article |
| id | doaj-art-adb8fa7a8a424e95945dab7dc530de3c |
| institution | DOAJ |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-adb8fa7a8a424e95945dab7dc530de3c2025-08-20T03:02:48ZengMDPI AGApplied Sciences2076-34172025-08-011515862510.3390/app15158625Impact of <i>Kickxia elatine</i> In Vitro-Derived Stem Cells on the Biophysical Properties of Facial Skin: A Placebo-Controlled TrialAnastasia Aliesa Hermosaningtyas0Anna Kroma-Szal1Justyna Gornowicz-Porowska2Maria Urbanska3Anna Budzianowska4Małgorzata Kikowska5Doctoral School, Poznan University of Medical Sciences, 70 Bukowska St., 60-812 Poznan, PolandDepartment and Division of Practical Cosmetology and Skin Disease Prophylaxis, Poznan University of Medical Sciences, Collegium Pharmaceuticum, 3 Rokietnicka St., 60-806 Poznan, PolandDepartment and Division of Practical Cosmetology and Skin Disease Prophylaxis, Poznan University of Medical Sciences, Collegium Pharmaceuticum, 3 Rokietnicka St., 60-806 Poznan, PolandDepartment and Division of Practical Cosmetology and Skin Disease Prophylaxis, Poznan University of Medical Sciences, Collegium Pharmaceuticum, 3 Rokietnicka St., 60-806 Poznan, PolandLaboratory of Pharmaceutical Biology and Biotechnology, Department and Division of Practical Cosmetology and Skin Disease Prophylaxis, Poznan University of Medical Sciences, Collegium Pharmaceuticum, 3 Rokietnicka St., 60-806 Poznan, PolandLaboratory of Pharmaceutical Biology and Biotechnology, Department and Division of Practical Cosmetology and Skin Disease Prophylaxis, Poznan University of Medical Sciences, Collegium Pharmaceuticum, 3 Rokietnicka St., 60-806 Poznan, PolandThe growing demand for natural and sustainable skincare products has driven interest in plant-based active ingredients, especially from in vitro cultures. This placebo-controlled study investigated the impact of a facial cream containing 2% <i>Kickxia elatine</i> (L.) Dumort cell suspension culture extract on various skin biophysical parameters. The cream was applied to the cheek once daily for six weeks on 40 healthy female volunteers between the ages of 40 to 49. The evaluated skin parameters including skin hydration, transepidermal water loss (TEWL), erythema intensity (EI), melanin intensity (MI), skin surface pH, and skin structure, wrinkle depth, vascular lesions, and vascular discolouration. The results indicated that significant improvements were observed in skin hydration (from 40.36 to 63.00 AU, <i>p</i> < 0.001) and there was a decrease in TEWL score (14.82 to 11.76 g/h/m<sup>2</sup>, <i>p</i> < 0.001), while the skin surface pH was maintained (14.82 to 11.76 g/h/m<sup>2</sup>, <i>p</i> < 0.001). Moreover, the <i>K. elatine</i> cell extract significantly improved skin structure values (9.23 to 8.50, <i>p</i> = 0.028), reduced vascular lesions (2.72 to 1.54 mm<sup>2</sup>, <i>p</i> = 0.011), and lowered skin discolouration (20.98% to 14.84%, <i>p</i> < 0.001), indicating its moisturising, protective, brightening, and soothing properties. These findings support the potential use of <i>K. elatine</i> cell extract in dermocosmetic formulations targeting dry, sensitive, or ageing skin.https://www.mdpi.com/2076-3417/15/15/8625<i>Linaria elatine</i>cell suspension cultureplant stem cellsphytocompoundsphytocosmetic |
| spellingShingle | Anastasia Aliesa Hermosaningtyas Anna Kroma-Szal Justyna Gornowicz-Porowska Maria Urbanska Anna Budzianowska Małgorzata Kikowska Impact of <i>Kickxia elatine</i> In Vitro-Derived Stem Cells on the Biophysical Properties of Facial Skin: A Placebo-Controlled Trial Applied Sciences <i>Linaria elatine</i> cell suspension culture plant stem cells phytocompounds phytocosmetic |
| title | Impact of <i>Kickxia elatine</i> In Vitro-Derived Stem Cells on the Biophysical Properties of Facial Skin: A Placebo-Controlled Trial |
| title_full | Impact of <i>Kickxia elatine</i> In Vitro-Derived Stem Cells on the Biophysical Properties of Facial Skin: A Placebo-Controlled Trial |
| title_fullStr | Impact of <i>Kickxia elatine</i> In Vitro-Derived Stem Cells on the Biophysical Properties of Facial Skin: A Placebo-Controlled Trial |
| title_full_unstemmed | Impact of <i>Kickxia elatine</i> In Vitro-Derived Stem Cells on the Biophysical Properties of Facial Skin: A Placebo-Controlled Trial |
| title_short | Impact of <i>Kickxia elatine</i> In Vitro-Derived Stem Cells on the Biophysical Properties of Facial Skin: A Placebo-Controlled Trial |
| title_sort | impact of i kickxia elatine i in vitro derived stem cells on the biophysical properties of facial skin a placebo controlled trial |
| topic | <i>Linaria elatine</i> cell suspension culture plant stem cells phytocompounds phytocosmetic |
| url | https://www.mdpi.com/2076-3417/15/15/8625 |
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