Cytokines in Clinical and Experimental Transplantation
Allograft rejection is a complex process, which requires interactions between different cell types and a variety of soluble factors, such as cytokines. In this review we discuss the role of cytokines in the induction and effector phases of the rejection process and in the induction and maintenance o...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000566 |
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| _version_ | 1849766829547847680 |
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| author | Ann C. T. M. Vossen Huub F. J. Savelkoul |
| author_facet | Ann C. T. M. Vossen Huub F. J. Savelkoul |
| author_sort | Ann C. T. M. Vossen |
| collection | DOAJ |
| description | Allograft rejection is a complex process, which requires
interactions between different cell types and a variety of soluble
factors, such as cytokines. In this review we discuss the role of
cytokines in the induction and effector phases of the rejection
process and in the induction and maintenance of allospecific graft
tolerance. Furthermore, we discuss the feasibility of clinical graft
function monitoring by measuring cytokines and the possibilities for
intervention in the cytokine network in order to inhibit graft
rejection and eventually obtain graft acceptance. |
| format | Article |
| id | doaj-art-adb7137bccfe422198f5193c917dfd8c |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-adb7137bccfe422198f5193c917dfd8c2025-08-20T03:04:26ZengWileyMediators of Inflammation0962-93511466-18611994-01-013640341010.1155/S0962935194000566Cytokines in Clinical and Experimental TransplantationAnn C. T. M. Vossen0Huub F. J. Savelkoul1Department of Immunology, Erasmus University, PO Box 1738, Rotterdam 3000 DR, The NetherlandsDepartment of Immunology, Erasmus University, PO Box 1738, Rotterdam 3000 DR, The NetherlandsAllograft rejection is a complex process, which requires interactions between different cell types and a variety of soluble factors, such as cytokines. In this review we discuss the role of cytokines in the induction and effector phases of the rejection process and in the induction and maintenance of allospecific graft tolerance. Furthermore, we discuss the feasibility of clinical graft function monitoring by measuring cytokines and the possibilities for intervention in the cytokine network in order to inhibit graft rejection and eventually obtain graft acceptance.http://dx.doi.org/10.1155/S0962935194000566 |
| spellingShingle | Ann C. T. M. Vossen Huub F. J. Savelkoul Cytokines in Clinical and Experimental Transplantation Mediators of Inflammation |
| title | Cytokines in Clinical and Experimental Transplantation |
| title_full | Cytokines in Clinical and Experimental Transplantation |
| title_fullStr | Cytokines in Clinical and Experimental Transplantation |
| title_full_unstemmed | Cytokines in Clinical and Experimental Transplantation |
| title_short | Cytokines in Clinical and Experimental Transplantation |
| title_sort | cytokines in clinical and experimental transplantation |
| url | http://dx.doi.org/10.1155/S0962935194000566 |
| work_keys_str_mv | AT annctmvossen cytokinesinclinicalandexperimentaltransplantation AT huubfjsavelkoul cytokinesinclinicalandexperimentaltransplantation |