Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles
Abstract Extracellular vesicles (EVs) hold significant promise for the prevention and treatment of various diseases. However, the translation of EV‐based therapies into clinical practice faces considerable challenges, particularly in terms of production yield and therapeutic efficacy. Recent studies...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202503027 |
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| author | Bilu Xiang Shiying Zhang Irene Shuping Zhao Xueqi Gan Yang Zhang |
| author_facet | Bilu Xiang Shiying Zhang Irene Shuping Zhao Xueqi Gan Yang Zhang |
| author_sort | Bilu Xiang |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) hold significant promise for the prevention and treatment of various diseases. However, the translation of EV‐based therapies into clinical practice faces considerable challenges, particularly in terms of production yield and therapeutic efficacy. Recent studies have emphasized the heterogeneity of EVs and the influence of parental cell microenvironmental signals on their biogenesis, cargo composition, and therapeutic outcomes. This review offers a comprehensive overview of strategies to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation. Additionally, it explores how microenvironmental signals affect EV cargoes and the mechanisms by which these signals can improve therapeutic efficacy. The review also addresses current challenges and potential solutions to accelerate the clinical translation of EV therapies. Ultimately, it highlights the potential of microenvironmental modulation in unlocking the full therapeutic capacity of EVs, providing key insights into their production and clinical use for treating various diseases. |
| format | Article |
| id | doaj-art-adb38577e1a44f2eb7026dc892d0de21 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-adb38577e1a44f2eb7026dc892d0de212025-08-20T03:11:14ZengWileyAdvanced Science2198-38442025-05-011218n/an/a10.1002/advs.202503027Microenvironmental Modulation for Therapeutic Efficacy of Extracellular VesiclesBilu Xiang0Shiying Zhang1Irene Shuping Zhao2Xueqi Gan3Yang Zhang4School of Dentistry Shenzhen University Medical School Shenzhen 518055 ChinaSchool of Dentistry Shenzhen University Medical School Shenzhen 518055 ChinaSchool of Dentistry Shenzhen University Medical School Shenzhen 518055 ChinaState Key Laboratory of Oral Disease National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu 610041 ChinaSchool of Dentistry Shenzhen University Medical School Shenzhen 518055 ChinaAbstract Extracellular vesicles (EVs) hold significant promise for the prevention and treatment of various diseases. However, the translation of EV‐based therapies into clinical practice faces considerable challenges, particularly in terms of production yield and therapeutic efficacy. Recent studies have emphasized the heterogeneity of EVs and the influence of parental cell microenvironmental signals on their biogenesis, cargo composition, and therapeutic outcomes. This review offers a comprehensive overview of strategies to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation. Additionally, it explores how microenvironmental signals affect EV cargoes and the mechanisms by which these signals can improve therapeutic efficacy. The review also addresses current challenges and potential solutions to accelerate the clinical translation of EV therapies. Ultimately, it highlights the potential of microenvironmental modulation in unlocking the full therapeutic capacity of EVs, providing key insights into their production and clinical use for treating various diseases.https://doi.org/10.1002/advs.202503027exosomesextracellular vesiclesmicroenvironmentstimulitherapeutic efficacy |
| spellingShingle | Bilu Xiang Shiying Zhang Irene Shuping Zhao Xueqi Gan Yang Zhang Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles Advanced Science exosomes extracellular vesicles microenvironment stimuli therapeutic efficacy |
| title | Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles |
| title_full | Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles |
| title_fullStr | Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles |
| title_full_unstemmed | Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles |
| title_short | Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles |
| title_sort | microenvironmental modulation for therapeutic efficacy of extracellular vesicles |
| topic | exosomes extracellular vesicles microenvironment stimuli therapeutic efficacy |
| url | https://doi.org/10.1002/advs.202503027 |
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