Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes

Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes

Detergents and lipid nanodiscs affect the cryo-EM structures of pentameric ligand-gated ion channels (pLGICs) including ELIC. To determine the structure of a pLGIC in a membrane environment that supports ion channel function, we performed single particle cryo-EM of ELIC in liposomes. ELIC activation...

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Bibliographic Details
Main Authors: Vikram Dalal, Brandon K Tan, Hanrui Xu, Wayland WL Cheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
ligand-gated ion channel
cryo-EM
liposomes
nanodiscs
Online Access:https://elifesciences.org/articles/106728
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