Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCC

Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCC

IntroductionThe role of mast cells (MCs) in clear cell renal carcinoma (ccRCC) is unclear, and comprehensive single-cell studies of ccRCC MCs have not yet been performed.MethodsTo investigate the heterogeneity and effects of MCs in ccRCC, we studied single-cell transcriptomes from four ccRCC patient...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiyu Song, Jianhua Jiao, Jiayang Qin, Wei Zhang, Weijun Qin, Shuaijun Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Immunology
Subjects:	mast cell clear cell renal cell carcinoma single-cell RNA sequencing heterogeneity spatial transcriptomics prognosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1494025/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Study on the mechanism of BGN in progression and metastasis of ccRCC
by: Hanqing Xia, et al.
Published: (2025-03-01)

Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction
by: Fang Lyu, et al.
Published: (2025-01-01)

Regulatory T cells and matrix-producing cancer associated fibroblasts contribute on the immune resistance and progression of prognosis related tumor subtypes in ccRCC
by: Chao Zhang, et al.
Published: (2025-07-01)

Preoperative prediction of WHO/ISUP grade of ccRCC using intratumoral and peritumoral habitat imaging: multicenter study
by: Zhihui Chen, et al.
Published: (2025-05-01)

Integrated transcriptome analysis and combinatorial machine learning to construct a homeostatic model of acetylation for ccRCC and validate the key gene GCNT4
by: Baohua Zhu, et al.
Published: (2025-06-01)

Bone marrow mast cells and mast cell tryptase in plasma cell disorders
by: Raveena Yadav, et al.
Published: (2025-03-01)

An integrated bioinformatic investigation of succinic acid metabolism related genes in ccRCC followed by preliminary validation of SLC25A4 in tumorigenesis
by: Dong Yue, et al.
Published: (2025-06-01)

Mast cell activation syndrome: The overdiagnosis problems
by: N. V. Mikryukova, et al.
Published: (2025-06-01)

Mast Cell Frequency in Oral Squamous Cell Carcinoma
by: Najmeh Jafari, et al.
Published: (2025-02-01)

TRIP13-induced NUSAP1 upregulation promotes CcRCC progression through EMT and PI3K/AKT/mTOR pathway
by: Xiaolong Chen, et al.
Published: (2025-08-01)

Mast cells in lung of rat
by: I. Ivanova
Published: (2017-09-01)

Role of mast cells in the pathogenesis of oral submucous fibrosis: a systematic review and meta-analysis
by: Laliytha Kumar Bijai, et al.
Published: (2024-10-01)

Interrelation of mast cells with spermatogenesis in norm and in case of damage
by: Yu. S. Khramtsova, et al.
Published: (2019-05-01)

Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma
by: Isadora Luana Flores, et al.
Published: (2024-12-01)

Connective tissue mast cells store and release noradrenaline
by: Yusuke Otani, et al.
Published: (2023-10-01)

The role of mast cells in allergic rhinitis
by: Jin Zhang, et al.
Published: (2025-07-01)

Mast cell subsets and neuropeptides in leprosy reactions
by: Antunes Sérgio Luiz Gomes, et al.
Published: (2003-01-01)

Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis
by: Katie Ridge, et al.
Published: (2025-09-01)

BAP1 complexes with YY1 and RBBP7 and its downstream targets in ccRCC cells
by: Wu Ying, et al.
Published: (2025-07-01)

Expanding the scope of mast cell disease: Does mast cell‐derived TNF play a role in immune‐mediated chronic illness and autoimmunity?
by: Rachel da Silveira Gorman, et al.
Published: (2024-12-01)

Immunogenic cell death signature predicts survival and reveals the role of VEGFA + Mast cells in lung adenocarcinoma
by: Meng Zhang, et al.
Published: (2025-02-01)

MAST CELLS ARE KEY PARTICIPANTS IN THE PATHOGENESIS OF IMMUNOINFLAMMATORY DISEASES
by: E. O. Baglay, et al.
Published: (2015-04-01)

Quantification of mast cells in different stages of periodontal disease
by: Marjanović Dragan, et al.
Published: (2016-01-01)

Organic cation transporter-3 mediates exogenous histamine uptake by primary mast cells
by: Thuy-An Nguyen, MD, et al.
Published: (2025-08-01)

MAST CELL REACTION TO ACUPUNCTURE ON TONGUE
by: N. Pirovski, et al.
Published: (2019-09-01)

Characterisation of the Faecal Microbiota in Dogs with Mast Cell Tumours Compared with Healthy Dogs
by: Catarina Aluai-Cunha, et al.
Published: (2025-07-01)

Establishment and characterisation of a novel canine mast cell tumour cell line (C18)
by: Sudchaya Bhanpattanakul, et al.
Published: (2025-03-01)

IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms
by: Jing Wang, et al.
Published: (2014-06-01)

Is there any role of mast cell density and microvessel density in cervical squamous cell carcinoma? A histologic study with special reference to CD-34 immunomarker staining
by: Santosh Kumar Mondal, et al.
Published: (2014-01-01)

Presence of mast cells and the expression of metalloproteinase 9 in the gingiva of ovariectomized rats with periodontal disease
by: Vanessa Ávila Sarmento Silveira, et al.
Published: (2018-01-01)

Synovial mast cells and osteoarthritis: Current understandings and future perspectives
by: Guanghui Hao, et al.
Published: (2024-12-01)

THE INFLUENCE OF HELICHRYSUM ARENARIUM FLOWERS INFUSION ON MAST CELLS DEGRANULATION IN VITRO
by: N. V. Karazhan
Published: (2018-03-01)

Modified Bismarck brown staining for demonstration of soft tissue mast cells
by: N. Tomov, et al.
Published: (2017-09-01)

Mast cell promotes obesity by activating microglia in hypothalamus
by: Wen Tian, et al.
Published: (2025-03-01)

Response to tigilanol tiglate in dogs with mast cell tumors
by: Margaret L. Musser, et al.
Published: (2024-11-01)

In vitro and in vivo Expression of InterstitialCollagenase/MMP-1 by Human Mast Cells
by: Nick Di Girolamo, et al.
Published: (2000-01-01)

Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps
by: Luca Giovanni Locatello, et al.
Published: (2024-11-01)

Treatment of patients with evidence of mast cell-mediated itch in the absence of hives with omalizumab
by: Kelsey L. Auyeung, et al.
Published: (2024-12-01)

Regenerative role of mast cells and mesenchymal stem cells in histopathology of the sciatic nerve and tibialis cranialis muscle, following denervation in rats
by: Zahra Bakhtiary, et al.
Published: (2024-12-01)

Case report: Experience of a rare case of primary acute mast cell leukemia
by: Zhijuan Pan, et al.
Published: (2025-01-01)