Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10

Despite evidence highlighting benefits of age 9/10 initiation of human papillomavirus (HPV) vaccination, little is known about who is initiating the series earlier. We describe the population of children who initiate earlier and assess the relationship of earlier initiation with series completion. W...

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Main Authors: Grace W. Ryan, Amanda Kahl, Emily Janio, Bethany Kintigh, Don Callaghan, Natoshia M. Askelson
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Human Vaccines & Immunotherapeutics
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Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2025.2547432
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author Grace W. Ryan
Amanda Kahl
Emily Janio
Bethany Kintigh
Don Callaghan
Natoshia M. Askelson
author_facet Grace W. Ryan
Amanda Kahl
Emily Janio
Bethany Kintigh
Don Callaghan
Natoshia M. Askelson
author_sort Grace W. Ryan
collection DOAJ
description Despite evidence highlighting benefits of age 9/10 initiation of human papillomavirus (HPV) vaccination, little is known about who is initiating the series earlier. We describe the population of children who initiate earlier and assess the relationship of earlier initiation with series completion. We used individual-level immunization registry data from Iowa which contained data on male (49.9%) and female (50.1%) children born between 2004–2013 ages 9 and 17. We compared sociodemographic characteristics using chi-square statistics and used logistic regression to assess odds of initiation. Of children with a record of HPV vaccination, only 3.2% initiated early. In comparison to children who initiated at later, the early initiator group had a higher percentage of females (p < .0001), greater representation of nonwhite children (p < .0001), higher percentage living in urban areas (p < .0001) and higher private insurance (p < .0001). In logistic regression models, earlier initiation was significantly associated with higher rates of on-time completion (OR: 10.8 (8.6, 13.5)). These results can support prioritization of efforts to promote earlier initiation. For example, rural areas may need targeted outreach. Future work could integrate geospatial analyses so that local organizations could be able to target specific counties or even zip codes with the lowest rates of initiation.
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spelling doaj-art-ada3e48306c447ea951e4abc45a321d52025-08-20T03:46:45ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2547432Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10Grace W. Ryan0Amanda Kahl1Emily Janio2Bethany Kintigh3Don Callaghan4Natoshia M. Askelson5Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USAIowa Cancer Registry, University of Iowa, Iowa City, IA, USADepartment of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa City, IA, USAIowa Department of Health and Human Services, University of Iowa, Des Moines, IA, USAIowa Department of Health and Human Services, University of Iowa, Des Moines, IA, USADepartment of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa City, IA, USADespite evidence highlighting benefits of age 9/10 initiation of human papillomavirus (HPV) vaccination, little is known about who is initiating the series earlier. We describe the population of children who initiate earlier and assess the relationship of earlier initiation with series completion. We used individual-level immunization registry data from Iowa which contained data on male (49.9%) and female (50.1%) children born between 2004–2013 ages 9 and 17. We compared sociodemographic characteristics using chi-square statistics and used logistic regression to assess odds of initiation. Of children with a record of HPV vaccination, only 3.2% initiated early. In comparison to children who initiated at later, the early initiator group had a higher percentage of females (p < .0001), greater representation of nonwhite children (p < .0001), higher percentage living in urban areas (p < .0001) and higher private insurance (p < .0001). In logistic regression models, earlier initiation was significantly associated with higher rates of on-time completion (OR: 10.8 (8.6, 13.5)). These results can support prioritization of efforts to promote earlier initiation. For example, rural areas may need targeted outreach. Future work could integrate geospatial analyses so that local organizations could be able to target specific counties or even zip codes with the lowest rates of initiation.https://www.tandfonline.com/doi/10.1080/21645515.2025.2547432HPV vaccineimmunization registryrural health
spellingShingle Grace W. Ryan
Amanda Kahl
Emily Janio
Bethany Kintigh
Don Callaghan
Natoshia M. Askelson
Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10
Human Vaccines & Immunotherapeutics
HPV vaccine
immunization registry
rural health
title Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10
title_full Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10
title_fullStr Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10
title_full_unstemmed Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10
title_short Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10
title_sort using immunization registry data to explore initiation of hpv vaccination at ages 9 and 10
topic HPV vaccine
immunization registry
rural health
url https://www.tandfonline.com/doi/10.1080/21645515.2025.2547432
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