Advances and challenges in cancer immunotherapy: mechanisms, clinical applications, and future directions

Advances and challenges in cancer immunotherapy: mechanisms, clinical applications, and future directions

Cancer is a major threat to public health today, particularly due to the emergence of drug resistance and disease re-emergence post-traditional treatment. Regulatory T cells (Tregs) support cancer progression through their immunosuppressive mechanisms expressing co-inhibitory molecules like programm...

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Bibliographic Details
Main Authors: Neeharika Vatsavai, Sumeet Kaur Bhinder, Rahaman Shaik, Shaheen Mahira, Shruti Kapoor, Md Shadab Ali, Deepak Verma, Jay Singh, Sreelakshmi Badavenkatappa Gari, Prabhat Upadhyay, Yeva Meshkovska, Chandraiah Godugu, Sowjanya Thatikonda, Venkatesh Pooladanda
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
cancer immunotherapy
regulatory T cells
immune checkpoints
PD-1
CTLA-4
tumor immune evasion
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1602529/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1602529/full

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