Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer
Abstract Background Current breast cancer (BC) diagnostics include detailed pathological and genetic analysis for biological subtype identification; however, throughout the course of the disease, new alterations determining the progression of the disease or resistance to treatment appear. The tests...
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Cambridge University Press
2025-01-01
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| Series: | Expert Reviews in Molecular Medicine |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399425100082/type/journal_article |
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| author | Ieva Sadzeviciene Danielius Kaubrys Sonata Jarmalaite |
| author_facet | Ieva Sadzeviciene Danielius Kaubrys Sonata Jarmalaite |
| author_sort | Ieva Sadzeviciene |
| collection | DOAJ |
| description | Abstract
Background
Current breast cancer (BC) diagnostics include detailed pathological and genetic analysis for biological subtype identification; however, throughout the course of the disease, new alterations determining the progression of the disease or resistance to treatment appear. The tests based on liquid biopsy allow minimally invasive real-time monitoring of tumour-specific alteration during the entire disease treatment. Tumour-specific genetic material fragments occur in bodily fluids, and cell-free nucleic acids are a convenient tool for analysing genetic and epigenetic changes in tumours. Evidence for the diagnostic and prognostic value of epigenetic biomarkers is gradually increasing. Although, up to date, there is limited access to in vitro diagnostic (IVD) epigenetic liquid biopsy-based tests for BC management, the data on the clinical potential of such tests and biomarkers are accumulating rapidly.
Methods
In this review, we focused on research involving cell-free DNA methylation biomarkers in blood serum or plasma samples from BC patients.
Results
Our review systematises data from genome-wide and targeted studies of DNA methylation changes in liquid biopsies from BC patients, aiming to highlight the most critical biomarkers suitable for early BC diagnosis, treatment personalisation and prognosis.
Conclusion
In summary, cell-free DNA methylation biomarkers show strong potential to enhance breast cancer diagnosis, prognosis, and personalised treatment through integrated clinical profiling.
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| format | Article |
| id | doaj-art-ada2759efcf44c5c857e16227876f366 |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-ada2759efcf44c5c857e16227876f3662025-08-20T12:57:28ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942025-01-012710.1017/erm.2025.10008Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast CancerIeva Sadzeviciene0https://orcid.org/0000-0003-1953-040XDanielius Kaubrys1Sonata Jarmalaite2Institute of Biosciences, Life Sciences Center, https://ror.org/03nadee84 Vilnius University , Vilnius, LithuaniaInstitute of Biosciences, Life Sciences Center, https://ror.org/03nadee84 Vilnius University , Vilnius, LithuaniaInstitute of Biosciences, Life Sciences Center, https://ror.org/03nadee84 Vilnius University , Vilnius, Lithuania https://ror.org/04w2jh416 National Cancer Institute , Biobank, Vilnius, LithuaniaAbstract Background Current breast cancer (BC) diagnostics include detailed pathological and genetic analysis for biological subtype identification; however, throughout the course of the disease, new alterations determining the progression of the disease or resistance to treatment appear. The tests based on liquid biopsy allow minimally invasive real-time monitoring of tumour-specific alteration during the entire disease treatment. Tumour-specific genetic material fragments occur in bodily fluids, and cell-free nucleic acids are a convenient tool for analysing genetic and epigenetic changes in tumours. Evidence for the diagnostic and prognostic value of epigenetic biomarkers is gradually increasing. Although, up to date, there is limited access to in vitro diagnostic (IVD) epigenetic liquid biopsy-based tests for BC management, the data on the clinical potential of such tests and biomarkers are accumulating rapidly. Methods In this review, we focused on research involving cell-free DNA methylation biomarkers in blood serum or plasma samples from BC patients. Results Our review systematises data from genome-wide and targeted studies of DNA methylation changes in liquid biopsies from BC patients, aiming to highlight the most critical biomarkers suitable for early BC diagnosis, treatment personalisation and prognosis. Conclusion In summary, cell-free DNA methylation biomarkers show strong potential to enhance breast cancer diagnosis, prognosis, and personalised treatment through integrated clinical profiling. https://www.cambridge.org/core/product/identifier/S1462399425100082/type/journal_articlebreast cancercell-free DNA (cfDNA)DNA hypermethylationDNA methylation biomarkersgenome-wide methylationliquid biopsy |
| spellingShingle | Ieva Sadzeviciene Danielius Kaubrys Sonata Jarmalaite Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer Expert Reviews in Molecular Medicine breast cancer cell-free DNA (cfDNA) DNA hypermethylation DNA methylation biomarkers genome-wide methylation liquid biopsy |
| title | Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer |
| title_full | Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer |
| title_fullStr | Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer |
| title_full_unstemmed | Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer |
| title_short | Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer |
| title_sort | liquid biopsy based dna methylation biomarkers for precision medicine in breast cancer |
| topic | breast cancer cell-free DNA (cfDNA) DNA hypermethylation DNA methylation biomarkers genome-wide methylation liquid biopsy |
| url | https://www.cambridge.org/core/product/identifier/S1462399425100082/type/journal_article |
| work_keys_str_mv | AT ievasadzeviciene liquidbiopsybaseddnamethylationbiomarkersforprecisionmedicineinbreastcancer AT danieliuskaubrys liquidbiopsybaseddnamethylationbiomarkersforprecisionmedicineinbreastcancer AT sonatajarmalaite liquidbiopsybaseddnamethylationbiomarkersforprecisionmedicineinbreastcancer |