The Experimental Study on Promoting the Ilizarov Distraction Osteogenesis by the Injection of Liquid Alg/nHAC Biocomposites
Limb lengthening is frequently utilized in treating limb length inequalities, angulation deformities, nonunions, complex fractures, and deficiencies after tumor resection in more recent year. The procedure of limb lengthening pioneered by Ilizarov is now a widely accepted method for correcting limb...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2014/238247 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850170007091150848 |
|---|---|
| author | Xinhui Liu Di Yu Jieyan Xu Chao Zhu Qingling Feng Chuanyong Hou Hua Wang Yelin Yang Guoping Guan |
| author_facet | Xinhui Liu Di Yu Jieyan Xu Chao Zhu Qingling Feng Chuanyong Hou Hua Wang Yelin Yang Guoping Guan |
| author_sort | Xinhui Liu |
| collection | DOAJ |
| description | Limb lengthening is frequently utilized in treating limb length inequalities, angulation deformities, nonunions, complex fractures, and deficiencies after tumor resection in more recent year. The procedure of limb lengthening pioneered by Ilizarov is now a widely accepted method for correcting limb length inequality and short stature as well as for bridging large defects in long bones. In order to promote bone healing during distraction osteogenesis and reduce the complications caused by limb lengthening pioneered, an alginate/nanohydroxyapatite/collagen (Alg/nHAC) composite was fabricated. General observation, histologically morphological observations, X-ray examination, biomechanical test, bone density, and the percentage area of bone trabecula were used to assay the ability of Alg/nHAC composite to promote bone healing. The present study demonstrates that the injection of liquid Alg/nHAC composites can significantly promote distraction osteogenesis. Alg/nHAC composite is promising for clinical application, solving the healing problem of backbone osteotomy and the fixing problem of metaphyseal backbone. |
| format | Article |
| id | doaj-art-ad9cbab00fa9475f902e2526aed2d81f |
| institution | OA Journals |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-ad9cbab00fa9475f902e2526aed2d81f2025-08-20T02:20:34ZengWileyInternational Journal of Polymer Science1687-94221687-94302014-01-01201410.1155/2014/238247238247The Experimental Study on Promoting the Ilizarov Distraction Osteogenesis by the Injection of Liquid Alg/nHAC BiocompositesXinhui Liu0Di Yu1Jieyan Xu2Chao Zhu3Qingling Feng4Chuanyong Hou5Hua Wang6Yelin Yang7Guoping Guan8Orthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaOrthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaOrthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaOrthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaState Key Laboratory of New Ceramic and Fine Processing, Tsinghua University, Beijing 100084, ChinaOrthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaOrthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaOrthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaOrthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaLimb lengthening is frequently utilized in treating limb length inequalities, angulation deformities, nonunions, complex fractures, and deficiencies after tumor resection in more recent year. The procedure of limb lengthening pioneered by Ilizarov is now a widely accepted method for correcting limb length inequality and short stature as well as for bridging large defects in long bones. In order to promote bone healing during distraction osteogenesis and reduce the complications caused by limb lengthening pioneered, an alginate/nanohydroxyapatite/collagen (Alg/nHAC) composite was fabricated. General observation, histologically morphological observations, X-ray examination, biomechanical test, bone density, and the percentage area of bone trabecula were used to assay the ability of Alg/nHAC composite to promote bone healing. The present study demonstrates that the injection of liquid Alg/nHAC composites can significantly promote distraction osteogenesis. Alg/nHAC composite is promising for clinical application, solving the healing problem of backbone osteotomy and the fixing problem of metaphyseal backbone.http://dx.doi.org/10.1155/2014/238247 |
| spellingShingle | Xinhui Liu Di Yu Jieyan Xu Chao Zhu Qingling Feng Chuanyong Hou Hua Wang Yelin Yang Guoping Guan The Experimental Study on Promoting the Ilizarov Distraction Osteogenesis by the Injection of Liquid Alg/nHAC Biocomposites International Journal of Polymer Science |
| title | The Experimental Study on Promoting the Ilizarov Distraction Osteogenesis by the Injection of Liquid Alg/nHAC Biocomposites |
| title_full | The Experimental Study on Promoting the Ilizarov Distraction Osteogenesis by the Injection of Liquid Alg/nHAC Biocomposites |
| title_fullStr | The Experimental Study on Promoting the Ilizarov Distraction Osteogenesis by the Injection of Liquid Alg/nHAC Biocomposites |
| title_full_unstemmed | The Experimental Study on Promoting the Ilizarov Distraction Osteogenesis by the Injection of Liquid Alg/nHAC Biocomposites |
| title_short | The Experimental Study on Promoting the Ilizarov Distraction Osteogenesis by the Injection of Liquid Alg/nHAC Biocomposites |
| title_sort | experimental study on promoting the ilizarov distraction osteogenesis by the injection of liquid alg nhac biocomposites |
| url | http://dx.doi.org/10.1155/2014/238247 |
| work_keys_str_mv | AT xinhuiliu theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT diyu theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT jieyanxu theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT chaozhu theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT qinglingfeng theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT chuanyonghou theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT huawang theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT yelinyang theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT guopingguan theexperimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT xinhuiliu experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT diyu experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT jieyanxu experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT chaozhu experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT qinglingfeng experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT chuanyonghou experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT huawang experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT yelinyang experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites AT guopingguan experimentalstudyonpromotingtheilizarovdistractionosteogenesisbytheinjectionofliquidalgnhacbiocomposites |