Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke
Background and purposePosterior circulation stroke patients have worse outcomes after mechanical thrombectomy (MT) and higher mortality than anterior circulation acute ischemic stroke (AIS) patients due to large vessel occlusions (LVOs). To determine the ideal recanalization device for posterior cir...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1620092/full |
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| author | Linlin Ma Zhe Cheng Gary B. Rajah Gary B. Rajah Ho Jun Yun Xiaokun Geng Xiaokun Geng Xiaokun Geng Yuchuan Ding |
| author_facet | Linlin Ma Zhe Cheng Gary B. Rajah Gary B. Rajah Ho Jun Yun Xiaokun Geng Xiaokun Geng Xiaokun Geng Yuchuan Ding |
| author_sort | Linlin Ma |
| collection | DOAJ |
| description | Background and purposePosterior circulation stroke patients have worse outcomes after mechanical thrombectomy (MT) and higher mortality than anterior circulation acute ischemic stroke (AIS) patients due to large vessel occlusions (LVOs). To determine the ideal recanalization device for posterior circulation LVO strokes, this study compared the operational parameters and prognosis among three commonly used thrombectomy devices.MethodsA total of 99 patients with posterior circulation AIS who underwent mechanical thrombectomy were enrolled. The patients were divided into three groups based on the different thrombectomy devices used during the procedure. Patient demographics, procedural metrics, functional outcomes, and symptomatic intracranial hemorrhage (sICH) were assessed. Any association between the devices and favorable clinical outcomes was assessed by logistic regression analysis.ResultsA total of 80 patients were analyzed. The Penumbra aspiration catheter revealed a significant advantage for the time of recanalization vs. the other devices (32 min vs. 44 and 41 min). No significant difference was observed in other procedural parameters or functional outcome. There was no significant difference in symptomatic cerebral hemorrhage (sICH), mortality, or functional independence after MT among the three groups. Diabetes mellitus, NIHSS score at admission, time from onset to recanalization, and occlusion site were associated with functional independence at 90 days, though the use of different recanalization devices did not make a significant difference.ConclusionAspiration achieved vessel recanalization faster than the retriever stent during mechanical thrombectomy in posterior circulation AIS. No clear improved functional outcome favored one device over another in this study. The key factors affecting functional outcomes in posterior circulation LVOs were the presence or absence of diabetes, baseline NIHSS, occlusion site of basilar artery, and TOR time. |
| format | Article |
| id | doaj-art-ad8d7989ec3d4d108ac2a0dbc1292a9a |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-ad8d7989ec3d4d108ac2a0dbc1292a9a2025-08-20T03:32:36ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.16200921620092Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation strokeLinlin Ma0Zhe Cheng1Gary B. Rajah2Gary B. Rajah3Ho Jun Yun4Xiaokun Geng5Xiaokun Geng6Xiaokun Geng7Yuchuan Ding8Department of Neurology and Stroke Center, Beijing Luhe Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology and Stroke Center, Beijing Luhe Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Munson Medical Center, Traverse City, MI, United StatesDepartment of Neurosurgery, Munson Healthcare, Traverse City, MI, United StatesDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Neurology and Stroke Center, Beijing Luhe Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United StatesLuhe Institute of Neuroscience, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United StatesBackground and purposePosterior circulation stroke patients have worse outcomes after mechanical thrombectomy (MT) and higher mortality than anterior circulation acute ischemic stroke (AIS) patients due to large vessel occlusions (LVOs). To determine the ideal recanalization device for posterior circulation LVO strokes, this study compared the operational parameters and prognosis among three commonly used thrombectomy devices.MethodsA total of 99 patients with posterior circulation AIS who underwent mechanical thrombectomy were enrolled. The patients were divided into three groups based on the different thrombectomy devices used during the procedure. Patient demographics, procedural metrics, functional outcomes, and symptomatic intracranial hemorrhage (sICH) were assessed. Any association between the devices and favorable clinical outcomes was assessed by logistic regression analysis.ResultsA total of 80 patients were analyzed. The Penumbra aspiration catheter revealed a significant advantage for the time of recanalization vs. the other devices (32 min vs. 44 and 41 min). No significant difference was observed in other procedural parameters or functional outcome. There was no significant difference in symptomatic cerebral hemorrhage (sICH), mortality, or functional independence after MT among the three groups. Diabetes mellitus, NIHSS score at admission, time from onset to recanalization, and occlusion site were associated with functional independence at 90 days, though the use of different recanalization devices did not make a significant difference.ConclusionAspiration achieved vessel recanalization faster than the retriever stent during mechanical thrombectomy in posterior circulation AIS. No clear improved functional outcome favored one device over another in this study. The key factors affecting functional outcomes in posterior circulation LVOs were the presence or absence of diabetes, baseline NIHSS, occlusion site of basilar artery, and TOR time.https://www.frontiersin.org/articles/10.3389/fneur.2025.1620092/fullacute ischemic strokeendovascular therapypenumbra aspiration cathetersolitaire retriever stenttrevo retriever stentprognosis |
| spellingShingle | Linlin Ma Zhe Cheng Gary B. Rajah Gary B. Rajah Ho Jun Yun Xiaokun Geng Xiaokun Geng Xiaokun Geng Yuchuan Ding Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke Frontiers in Neurology acute ischemic stroke endovascular therapy penumbra aspiration catheter solitaire retriever stent trevo retriever stent prognosis |
| title | Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke |
| title_full | Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke |
| title_fullStr | Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke |
| title_full_unstemmed | Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke |
| title_short | Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke |
| title_sort | efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke |
| topic | acute ischemic stroke endovascular therapy penumbra aspiration catheter solitaire retriever stent trevo retriever stent prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1620092/full |
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