Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway

Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway

ABSTRACT Phillyrin (PHY), also known as forsythin, is an active constituent isolated from the fruit of Forsythia suspensa (Thunb.) Vahl (Oleaceae). It exhibits anti-inflammatory, anti-viral, and antioxidant properties. However, the precise impact of PHY on colitis induced by dextran sodium sulfate (...

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Bibliographic Details
Main Authors: Tong Li, Guiqiu Hu, Shoupeng Fu, Di Qin, Zheyu Song
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:Microbiology Spectrum
Subjects:
phillyrin
DSS
UC
gut microbiota
intestinal barrier
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02006-24
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