Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, expl...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3797802 |
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| _version_ | 1849395256900976640 |
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| author | Wenpeng Cui Xu Min Xiaohong Xu Bing Du Ping Luo |
| author_facet | Wenpeng Cui Xu Min Xiaohong Xu Bing Du Ping Luo |
| author_sort | Wenpeng Cui |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress. Thus, activation of Nrf2 seems to be a new choice for the treatment of DN. In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies. |
| format | Article |
| id | doaj-art-ad7c5d0598e64a57bb42c7399e218bf9 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ad7c5d0598e64a57bb42c7399e218bf92025-08-20T03:39:41ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/37978023797802Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic NephropathyWenpeng Cui0Xu Min1Xiaohong Xu2Bing Du3Ping Luo4Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaDepartment of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaDepartment of Cardiology, The First Hospital of Jilin University, Changchun, Jilin 130031, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaDiabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress. Thus, activation of Nrf2 seems to be a new choice for the treatment of DN. In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies.http://dx.doi.org/10.1155/2017/3797802 |
| spellingShingle | Wenpeng Cui Xu Min Xiaohong Xu Bing Du Ping Luo Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy Journal of Diabetes Research |
| title | Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy |
| title_full | Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy |
| title_fullStr | Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy |
| title_full_unstemmed | Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy |
| title_short | Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy |
| title_sort | role of nuclear factor erythroid 2 related factor 2 in diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2017/3797802 |
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