Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective study
Background Although several studies have reported an association between atherosclerosis-related diseases and COVID-19, the relationship between COVID-19 severity and atherosclerosis progression remains unclear. The aim of this study is to determine the coronary artery calcium score (CACS) prognosti...
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BMJ Publishing Group
2021-01-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/8/1/e000923.full |
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| author | Jiro Terada Yuichiro Takeshita Retsu Fujita Yasutaka Hirasawa Taku Kinoshita Yuri Isaka Toru Kinouchi Hiroshi Tajima Yuji Tada Shigeru Kiryu Kenji Tsushima |
| author_facet | Jiro Terada Yuichiro Takeshita Retsu Fujita Yasutaka Hirasawa Taku Kinoshita Yuri Isaka Toru Kinouchi Hiroshi Tajima Yuji Tada Shigeru Kiryu Kenji Tsushima |
| author_sort | Jiro Terada |
| collection | DOAJ |
| description | Background Although several studies have reported an association between atherosclerosis-related diseases and COVID-19, the relationship between COVID-19 severity and atherosclerosis progression remains unclear. The aim of this study is to determine the coronary artery calcium score (CACS) prognostic value in patients with COVID-19 using indices such as deterioration in oxygenation and CT images of the chest.Methods This was a single-centre retrospective study of 53 consecutive patients with COVID-19 in Narita who were admitted to our hospital between March 2020 and August 2020. CACS was calculated based on non-gated CT scans of the chest performed on admission day. The patients were divided into the following two groups based on CACS: group 1 (CACS ≥180, n=11) and group 2 (CACS <180, n=42). Following univariate analysis of the main variables, multivariate analysis of variables that may be associated with COVID-19 progression was performed.Results Multivariable logistic regression analysis of age, sex, smoking history, diabetes, hypertension, dyslipidaemia, number of days from symptom onset to hospitalisation and CACS of ≥180 was performed. It revealed that unlike CACS of <180, CACS of ≥180 is associated with exacerbation of oxygenation or CT images of the chest during hospitalisation (OR: 12.879, 95% CI: 1.399 to 380.401). Furthermore, this model of eight variables showed good calibration (Hosmer-Lemeshow p=0.119).Conclusion CACS may be a prognosis marker of COVID-19 severity. Although coronary artery calcification is not typically assessed in pneumonia cases, it may provide a valuable clinical indicator for predicting severe COVID-19 outcomes. |
| format | Article |
| id | doaj-art-ad783a7e67844b398ee266561df89d50 |
| institution | OA Journals |
| issn | 2052-4439 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj-art-ad783a7e67844b398ee266561df89d502025-08-20T02:33:06ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392021-01-018110.1136/bmjresp-2021-000923Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective studyJiro Terada0Yuichiro Takeshita1Retsu Fujita2Yasutaka Hirasawa3Taku Kinoshita4Yuri Isaka5Toru Kinouchi6Hiroshi Tajima7Yuji Tada8Shigeru Kiryu9Kenji Tsushima10Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanInnovation and Research Support Center, International University of Health and Welfare, Tokyo, JapanDepartment of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Radiology, International University of Health and Welfare Narita Hospital, Narita, JapanDepartment of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, JapanBackground Although several studies have reported an association between atherosclerosis-related diseases and COVID-19, the relationship between COVID-19 severity and atherosclerosis progression remains unclear. The aim of this study is to determine the coronary artery calcium score (CACS) prognostic value in patients with COVID-19 using indices such as deterioration in oxygenation and CT images of the chest.Methods This was a single-centre retrospective study of 53 consecutive patients with COVID-19 in Narita who were admitted to our hospital between March 2020 and August 2020. CACS was calculated based on non-gated CT scans of the chest performed on admission day. The patients were divided into the following two groups based on CACS: group 1 (CACS ≥180, n=11) and group 2 (CACS <180, n=42). Following univariate analysis of the main variables, multivariate analysis of variables that may be associated with COVID-19 progression was performed.Results Multivariable logistic regression analysis of age, sex, smoking history, diabetes, hypertension, dyslipidaemia, number of days from symptom onset to hospitalisation and CACS of ≥180 was performed. It revealed that unlike CACS of <180, CACS of ≥180 is associated with exacerbation of oxygenation or CT images of the chest during hospitalisation (OR: 12.879, 95% CI: 1.399 to 380.401). Furthermore, this model of eight variables showed good calibration (Hosmer-Lemeshow p=0.119).Conclusion CACS may be a prognosis marker of COVID-19 severity. Although coronary artery calcification is not typically assessed in pneumonia cases, it may provide a valuable clinical indicator for predicting severe COVID-19 outcomes.https://bmjopenrespres.bmj.com/content/8/1/e000923.full |
| spellingShingle | Jiro Terada Yuichiro Takeshita Retsu Fujita Yasutaka Hirasawa Taku Kinoshita Yuri Isaka Toru Kinouchi Hiroshi Tajima Yuji Tada Shigeru Kiryu Kenji Tsushima Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective study BMJ Open Respiratory Research |
| title | Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective study |
| title_full | Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective study |
| title_fullStr | Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective study |
| title_full_unstemmed | Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective study |
| title_short | Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective study |
| title_sort | coronary artery calcium score may be a novel predictor of covid 19 prognosis a retrospective study |
| url | https://bmjopenrespres.bmj.com/content/8/1/e000923.full |
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