Metformin and risk factors for chronic kidney disease in a European population based on Mendelian randomization

Metformin and risk factors for chronic kidney disease in a European population based on Mendelian randomization

Background Metformin, widely used for type 2 diabetes, raises concerns about its use in chronic kidney disease (CKD) due to risks like lactic acidosis and renal function impact. This study uses Mendelian randomization (MR) and summary data-based MR (SMR) to explore metformin’s potential causal relat...

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Bibliographic Details
Main Authors: Xiaopei Liu, Xingyao Li, Peng An, Qi Gao, Yanhong Zhao, Xingmin Shi, Xili Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Mendelian randomization
metformin
chronic kidney disease
summary data-based Mendelian randomization
causal relationship
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2486551
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