The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value
Glioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression. As a prevalent post-translational modification, methylation influences various biological functions, particularly RNA processing, by modulating splici...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1583039/full |
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| author | Shao-Ze Zhang Shao-Ze Zhang Shao-Ze Zhang Shao-Yan Liu Meng-Die Cheng Yin-Feng Zhang Jia-Wei Tian |
| author_facet | Shao-Ze Zhang Shao-Ze Zhang Shao-Ze Zhang Shao-Yan Liu Meng-Die Cheng Yin-Feng Zhang Jia-Wei Tian |
| author_sort | Shao-Ze Zhang |
| collection | DOAJ |
| description | Glioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression. As a prevalent post-translational modification, methylation influences various biological functions, particularly RNA processing, by modulating splicing, transport, and degradation of both mRNAs and noncoding RNAs. Key methylation types such as N6-methyladenosine (m6A), N5-methylcytosine (m5C), N7-methylguanosine (m7G), and N1-methyladenosine (m1A) are dynamically regulated by specific enzymes known as writers, erasers, and readers. Dysregulation of these modifications contributes to glioma pathophysiology, while offering potential biomarkers for early detection and promising therapeutic targets. This review explores the mechanistic roles of RNA methylation in glioma and highlights its translational implications, aiming to advance molecular diagnostics and targeted interventions in glioma treatment. |
| format | Article |
| id | doaj-art-ad664e5e8f9e4dc5a56a010d6583db22 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ad664e5e8f9e4dc5a56a010d6583db222025-08-20T02:33:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15830391583039The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic valueShao-Ze Zhang0Shao-Ze Zhang1Shao-Ze Zhang2Shao-Yan Liu3Meng-Die Cheng4Yin-Feng Zhang5Jia-Wei Tian6Department of Emergency Internal Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Hospital Infection of Management Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Emergency Internal Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, ChinaDepartment of Emergency Internal Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaGlioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression. As a prevalent post-translational modification, methylation influences various biological functions, particularly RNA processing, by modulating splicing, transport, and degradation of both mRNAs and noncoding RNAs. Key methylation types such as N6-methyladenosine (m6A), N5-methylcytosine (m5C), N7-methylguanosine (m7G), and N1-methyladenosine (m1A) are dynamically regulated by specific enzymes known as writers, erasers, and readers. Dysregulation of these modifications contributes to glioma pathophysiology, while offering potential biomarkers for early detection and promising therapeutic targets. This review explores the mechanistic roles of RNA methylation in glioma and highlights its translational implications, aiming to advance molecular diagnostics and targeted interventions in glioma treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1583039/fullepitranscriptomeM6Am5Cm7Gm1A |
| spellingShingle | Shao-Ze Zhang Shao-Ze Zhang Shao-Ze Zhang Shao-Yan Liu Meng-Die Cheng Yin-Feng Zhang Jia-Wei Tian The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value Frontiers in Immunology epitranscriptome M6A m5C m7G m1A |
| title | The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value |
| title_full | The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value |
| title_fullStr | The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value |
| title_full_unstemmed | The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value |
| title_short | The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value |
| title_sort | role of rna methylation in glioma progression mechanisms diagnostic implications and therapeutic value |
| topic | epitranscriptome M6A m5C m7G m1A |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1583039/full |
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