Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women
Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder, occurring in young women at reproductive age. This study was carried out to investigate the association between the fat mass and obesity associated gene (Omentin-1V109D gene) polymorphism with some physiological and bi...
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Corporation of Research and Industrial Development
2024-06-01
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| Series: | Iraqi Journal of Industrial Research |
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| Online Access: | http://ijoir.gov.iq/ijoir/index.php/jou/article/view/430 |
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| author | Lujaen A. Hameed Shiva Khezri Ilham A. Khalaf Zainab J. Ghaneim Alaa A. Al-Asadi |
| author_facet | Lujaen A. Hameed Shiva Khezri Ilham A. Khalaf Zainab J. Ghaneim Alaa A. Al-Asadi |
| author_sort | Lujaen A. Hameed |
| collection | DOAJ |
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Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder, occurring in young women at reproductive age. This study was carried out to investigate the association between the fat mass and obesity associated gene (Omentin-1V109D gene) polymorphism with some physiological and biochemical Parameters. The present study indicates to the association between PCOS patients and control groups according to the hormonal profile and there is a link between obesity and pathogenesis of hyperprolactinemia, our data showed highly significantly difference. This study shows demonstrated the comparison of the mean of selected Lipid profile between PCOS patients and control group involving (T. Cholesterol, Triglyceride, HDL, LDL and VLDL). The mean value of serum total cholesterol (T.C), Triglyceride, HDL, LDL and VLDL are highly significantly increased (p<0.01) in PCOS patients group compared with healthy group (control). It was found highly significant association (P≤0.01) of serum-FSH, serum-LH, testosterone and prolactin hormones. It was found the mean value of serum total cholesterol, triglyceride, HDL, LDL and VLDL are highly significantly (P≤0.01) increased in PCOS patients. The Omentin gene (V109D rs2274907A) polymorphism have a significant association with hyper LDL, in women with PCO, and may represent as a risk factor for PCOS incidence.
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| format | Article |
| id | doaj-art-ad6041a0e24a40b884bafdf41a738ea9 |
| institution | OA Journals |
| issn | 2788-712X |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Corporation of Research and Industrial Development |
| record_format | Article |
| series | Iraqi Journal of Industrial Research |
| spelling | doaj-art-ad6041a0e24a40b884bafdf41a738ea92025-08-20T02:38:05ZengCorporation of Research and Industrial DevelopmentIraqi Journal of Industrial Research2788-712X2024-06-0111110.53523/ijoirVol11I1ID430430Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenLujaen A. Hameed0Shiva Khezri1Ilham A. Khalaf2Zainab J. Ghaneim3Alaa A. Al-Asadi4Al-Razi Center for Research & Medical Kits Production/ Corporation of Research and Industrial Development, IraqDepartment of Biology, Faculty of Science, Urmia University, IranAl-Razi Center for Research & Medical Kits Production/ Corporation of Research and Industrial Development, IraqAl-Razi Center for Research & Medical Kits Production/ Corporation of Research and Industrial Development, IraqAl-Razi Center for Research & Medical Kits Production/ Corporation of Research and Industrial Development, Iraq Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder, occurring in young women at reproductive age. This study was carried out to investigate the association between the fat mass and obesity associated gene (Omentin-1V109D gene) polymorphism with some physiological and biochemical Parameters. The present study indicates to the association between PCOS patients and control groups according to the hormonal profile and there is a link between obesity and pathogenesis of hyperprolactinemia, our data showed highly significantly difference. This study shows demonstrated the comparison of the mean of selected Lipid profile between PCOS patients and control group involving (T. Cholesterol, Triglyceride, HDL, LDL and VLDL). The mean value of serum total cholesterol (T.C), Triglyceride, HDL, LDL and VLDL are highly significantly increased (p<0.01) in PCOS patients group compared with healthy group (control). It was found highly significant association (P≤0.01) of serum-FSH, serum-LH, testosterone and prolactin hormones. It was found the mean value of serum total cholesterol, triglyceride, HDL, LDL and VLDL are highly significantly (P≤0.01) increased in PCOS patients. The Omentin gene (V109D rs2274907A) polymorphism have a significant association with hyper LDL, in women with PCO, and may represent as a risk factor for PCOS incidence. http://ijoir.gov.iq/ijoir/index.php/jou/article/view/430Polycystic ovary syndromeOmentin-1V109D geneObesitySNPRFLP |
| spellingShingle | Lujaen A. Hameed Shiva Khezri Ilham A. Khalaf Zainab J. Ghaneim Alaa A. Al-Asadi Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women Iraqi Journal of Industrial Research Polycystic ovary syndrome Omentin-1V109D gene Obesity SNP RFLP |
| title | Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women |
| title_full | Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women |
| title_fullStr | Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women |
| title_full_unstemmed | Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women |
| title_short | Genetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi WomenGenetic Polymorphisms Study of Polycystic Ovary Syndrome Associated with Omentin-1V109D Gene in Iraqi Women |
| title_sort | genetic polymorphisms study of polycystic ovary syndrome associated with omentin 1v109d gene in iraqi womengenetic polymorphisms study of polycystic ovary syndrome associated with omentin 1v109d gene in iraqi women |
| topic | Polycystic ovary syndrome Omentin-1V109D gene Obesity SNP RFLP |
| url | http://ijoir.gov.iq/ijoir/index.php/jou/article/view/430 |
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