Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women
Disorder of maternal immune responses during pregnancy triggers immunological rejection of fetus antigens by maternal immune components, contribute to spontaneous abortion or miscarriage. The study was designed to concentrated on immunoglobulins (IgM, IgG and IgA) and complement elements (C3 and C4)...
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| Format: | Article |
| Language: | English |
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Sulaimani Polytechnic University
2018-07-01
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| Series: | Kurdistan Journal of Applied Research |
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| Online Access: | https://kjar.spu.edu.iq/index.php/kjar/article/view/210 |
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| author | Hiwa Abdulrahman Ahmad Mehri Mirhaj Muhammd salih Kamal Ahmed Khidir |
| author_facet | Hiwa Abdulrahman Ahmad Mehri Mirhaj Muhammd salih Kamal Ahmed Khidir |
| author_sort | Hiwa Abdulrahman Ahmad |
| collection | DOAJ |
| description | Disorder of maternal immune responses during pregnancy triggers immunological rejection of fetus antigens by maternal immune components, contribute to spontaneous abortion or miscarriage. The study was designed to concentrated on immunoglobulins (IgM, IgG and IgA) and complement elements (C3 and C4) serum levels changes in normal pregnant and abortion women. Study groups were classified into normal pregnant women (20), spontaneous abortion (30) and non-pregnant women (16) as a control group, attending to Shahid Dr. Khalid Hospital/Department of Gynecology and Obstetrics/Koya city. Serum levels of immunoglobulins (IgG, IgM, and IgA), complement proteins (C3 and C4) were determined and analyzed for normal pregnant, abortion and control groups by using Single Radial Immunodiffusion (SRID) technique. The results demonstrated that concentration of IgG levels in abortion differed significantly in compare to normal pregnancy (p ?0.05), while there were no significant differences in IgM and IgA serum levels among groups (p >0.05). Also, statistical analysis revealed that serum levels of C3 and C4 significantly decreased in abortion group compared to normal pregnant and non-pregnant groups (p ?0.05). Concluded that complement proteins (C3 andC4) are a good defense line during normal pregnancy, sometime activation (hyper-consuming) of complement elements may provoke spontaneous abortion, while immunoglobulins are a little role in inducing of miscarriage in pregnant women.
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| format | Article |
| id | doaj-art-ad571b080bb64b46a49166eeb9493443 |
| institution | Kabale University |
| issn | 2411-7684 2411-7706 |
| language | English |
| publishDate | 2018-07-01 |
| publisher | Sulaimani Polytechnic University |
| record_format | Article |
| series | Kurdistan Journal of Applied Research |
| spelling | doaj-art-ad571b080bb64b46a49166eeb94934432025-02-09T21:00:47ZengSulaimani Polytechnic UniversityKurdistan Journal of Applied Research2411-76842411-77062018-07-013210.24017/science.2018.2.21210Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted WomenHiwa Abdulrahman Ahmad0Mehri Mirhaj Muhammd salih1Kamal Ahmed Khidir2Science and Health Research Center, Faculty of Science and Health Research, Koya University Koya, Erbil, IraqRadiology Department, Koya Technical Institute, Erbil Polytechnic University Koya, Erbil, IraqAnimal Resource Department, University of Raparin Qaladuzi, Sulimani, IraqDisorder of maternal immune responses during pregnancy triggers immunological rejection of fetus antigens by maternal immune components, contribute to spontaneous abortion or miscarriage. The study was designed to concentrated on immunoglobulins (IgM, IgG and IgA) and complement elements (C3 and C4) serum levels changes in normal pregnant and abortion women. Study groups were classified into normal pregnant women (20), spontaneous abortion (30) and non-pregnant women (16) as a control group, attending to Shahid Dr. Khalid Hospital/Department of Gynecology and Obstetrics/Koya city. Serum levels of immunoglobulins (IgG, IgM, and IgA), complement proteins (C3 and C4) were determined and analyzed for normal pregnant, abortion and control groups by using Single Radial Immunodiffusion (SRID) technique. The results demonstrated that concentration of IgG levels in abortion differed significantly in compare to normal pregnancy (p ?0.05), while there were no significant differences in IgM and IgA serum levels among groups (p >0.05). Also, statistical analysis revealed that serum levels of C3 and C4 significantly decreased in abortion group compared to normal pregnant and non-pregnant groups (p ?0.05). Concluded that complement proteins (C3 andC4) are a good defense line during normal pregnancy, sometime activation (hyper-consuming) of complement elements may provoke spontaneous abortion, while immunoglobulins are a little role in inducing of miscarriage in pregnant women. https://kjar.spu.edu.iq/index.php/kjar/article/view/210Pregnant, Abortion, IgG, IgM, IgA, C3, C4. |
| spellingShingle | Hiwa Abdulrahman Ahmad Mehri Mirhaj Muhammd salih Kamal Ahmed Khidir Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women Kurdistan Journal of Applied Research Pregnant, Abortion, IgG, IgM, IgA, C3, C4. |
| title | Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women |
| title_full | Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women |
| title_fullStr | Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women |
| title_full_unstemmed | Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women |
| title_short | Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women |
| title_sort | complement protein and immunoglobulins serum levels in normal pregnant and spontaneous aborted women |
| topic | Pregnant, Abortion, IgG, IgM, IgA, C3, C4. |
| url | https://kjar.spu.edu.iq/index.php/kjar/article/view/210 |
| work_keys_str_mv | AT hiwaabdulrahmanahmad complementproteinandimmunoglobulinsserumlevelsinnormalpregnantandspontaneousabortedwomen AT mehrimirhajmuhammdsalih complementproteinandimmunoglobulinsserumlevelsinnormalpregnantandspontaneousabortedwomen AT kamalahmedkhidir complementproteinandimmunoglobulinsserumlevelsinnormalpregnantandspontaneousabortedwomen |