Insight into the Molecular Imaging of Alzheimer’s Disease
Alzheimer’s disease is a complex neurodegenerative disease affecting millions of individuals worldwide. Earlier it was diagnosed only via clinical assessments and confirmed by postmortem brain histopathology. The development of validated biomarkers for Alzheimer’s disease has given impetus to improv...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2016/7462014 |
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| _version_ | 1832567539984498688 |
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| author | Abishek Arora Neeta Bhagat |
| author_facet | Abishek Arora Neeta Bhagat |
| author_sort | Abishek Arora |
| collection | DOAJ |
| description | Alzheimer’s disease is a complex neurodegenerative disease affecting millions of individuals worldwide. Earlier it was diagnosed only via clinical assessments and confirmed by postmortem brain histopathology. The development of validated biomarkers for Alzheimer’s disease has given impetus to improve diagnostics and accelerate the development of new therapies. Functional imaging like positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), and proton magnetic resonance spectroscopy provides a means of detecting and characterising the regional changes in brain blood flow, metabolism, and receptor binding sites that are associated with Alzheimer’s disease. Multimodal neuroimaging techniques have indicated changes in brain structure and metabolic activity, and an array of neurochemical variations that are associated with neurodegenerative diseases. Radiotracer-based PET and SPECT potentially provide sensitive, accurate methods for the early detection of disease. This paper presents a review of neuroimaging modalities like PET, SPECT, and selected imaging biomarkers/tracers used for the early diagnosis of AD. Neuroimaging with such biomarkers and tracers could achieve a much higher diagnostic accuracy for AD and related disorders in the future. |
| format | Article |
| id | doaj-art-ad5625c87ca547b082538df5f56fe41b |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-ad5625c87ca547b082538df5f56fe41b2025-02-03T01:01:14ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962016-01-01201610.1155/2016/74620147462014Insight into the Molecular Imaging of Alzheimer’s DiseaseAbishek Arora0Neeta Bhagat1Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201303, IndiaAmity Institute of Biotechnology, Amity University Uttar Pradesh, Room No. 312, J3 Block, III Floor, Noida 201303, IndiaAlzheimer’s disease is a complex neurodegenerative disease affecting millions of individuals worldwide. Earlier it was diagnosed only via clinical assessments and confirmed by postmortem brain histopathology. The development of validated biomarkers for Alzheimer’s disease has given impetus to improve diagnostics and accelerate the development of new therapies. Functional imaging like positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), and proton magnetic resonance spectroscopy provides a means of detecting and characterising the regional changes in brain blood flow, metabolism, and receptor binding sites that are associated with Alzheimer’s disease. Multimodal neuroimaging techniques have indicated changes in brain structure and metabolic activity, and an array of neurochemical variations that are associated with neurodegenerative diseases. Radiotracer-based PET and SPECT potentially provide sensitive, accurate methods for the early detection of disease. This paper presents a review of neuroimaging modalities like PET, SPECT, and selected imaging biomarkers/tracers used for the early diagnosis of AD. Neuroimaging with such biomarkers and tracers could achieve a much higher diagnostic accuracy for AD and related disorders in the future.http://dx.doi.org/10.1155/2016/7462014 |
| spellingShingle | Abishek Arora Neeta Bhagat Insight into the Molecular Imaging of Alzheimer’s Disease International Journal of Biomedical Imaging |
| title | Insight into the Molecular Imaging of Alzheimer’s Disease |
| title_full | Insight into the Molecular Imaging of Alzheimer’s Disease |
| title_fullStr | Insight into the Molecular Imaging of Alzheimer’s Disease |
| title_full_unstemmed | Insight into the Molecular Imaging of Alzheimer’s Disease |
| title_short | Insight into the Molecular Imaging of Alzheimer’s Disease |
| title_sort | insight into the molecular imaging of alzheimer s disease |
| url | http://dx.doi.org/10.1155/2016/7462014 |
| work_keys_str_mv | AT abishekarora insightintothemolecularimagingofalzheimersdisease AT neetabhagat insightintothemolecularimagingofalzheimersdisease |