Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity
A highly potent strain of Lentinus edodes producing lentinomycin B, an erythadenin metabolite showing hypolipidemic activity, and biologically active water soluble endopolysaccharides was isolated. The optimum composition of the medium for the strain submerged cultivation was developed. The medium p...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/451 |
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| author | L. M. Krasnopolskaya N. Yu. Kats A. I. Usov A. V. Barkov V. A. Vinokurov |
| author_facet | L. M. Krasnopolskaya N. Yu. Kats A. I. Usov A. V. Barkov V. A. Vinokurov |
| author_sort | L. M. Krasnopolskaya |
| collection | DOAJ |
| description | A highly potent strain of Lentinus edodes producing lentinomycin B, an erythadenin metabolite showing hypolipidemic activity, and biologically active water soluble endopolysaccharides was isolated. The optimum composition of the medium for the strain submerged cultivation was developed. The medium provided shorter period of the strain cultivation and a 2-fold increase of the biomass yield and production of the endopolysaccharides up to 21 g/l and 4.8 g/l of the culture fluid respectively. The total fraction of the water soluble polysaccharides isolated from the mycelium contained glucose, galactose, mannose, arabinose and xylose as the neutral monosaccharides. Glucose was the main monosaccharide. The procedure of the strain submerged cultivation provided production of several final substances during a single technological cycle. |
| format | Article |
| id | doaj-art-ad53e70ade5a4a289e35a6025bda2805 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-ad53e70ade5a4a289e35a6025bda28052025-08-20T03:42:01ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01579-1037450Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological ActivityL. M. Krasnopolskaya0N. Yu. Kats1A. I. Usov2A. V. Barkov3V. A. Vinokurov4G. F. Gause Research Institute of New Antibiotics, Russian Academy of Medical SciencesG. F. Gause Research Institute of New Antibiotics, Russian Academy of Medical SciencesN. D. Zelinsky Institute of Organic Chemistry, Russian Academy of SciencesG. F. Gause Research Institute of New Antibiotics, Russian Academy of Medical SciencesI. M. Gubkin Russian State University of Petroleum and GasesA highly potent strain of Lentinus edodes producing lentinomycin B, an erythadenin metabolite showing hypolipidemic activity, and biologically active water soluble endopolysaccharides was isolated. The optimum composition of the medium for the strain submerged cultivation was developed. The medium provided shorter period of the strain cultivation and a 2-fold increase of the biomass yield and production of the endopolysaccharides up to 21 g/l and 4.8 g/l of the culture fluid respectively. The total fraction of the water soluble polysaccharides isolated from the mycelium contained glucose, galactose, mannose, arabinose and xylose as the neutral monosaccharides. Glucose was the main monosaccharide. The procedure of the strain submerged cultivation provided production of several final substances during a single technological cycle.https://www.antibiotics-chemotherapy.ru/jour/article/view/451lentinus edodessubmerged cultivationlentinus edodeslentinomycin b |
| spellingShingle | L. M. Krasnopolskaya N. Yu. Kats A. I. Usov A. V. Barkov V. A. Vinokurov Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity Антибиотики и Химиотерапия lentinus edodes submerged cultivation lentinus edodes lentinomycin b |
| title | Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity |
| title_full | Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity |
| title_fullStr | Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity |
| title_full_unstemmed | Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity |
| title_short | Submerged Cultivation of Lentinus edodes Strain with Broad Spectrum Biological Activity |
| title_sort | submerged cultivation of lentinus edodes strain with broad spectrum biological activity |
| topic | lentinus edodes submerged cultivation lentinus edodes lentinomycin b |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/451 |
| work_keys_str_mv | AT lmkrasnopolskaya submergedcultivationoflentinusedodesstrainwithbroadspectrumbiologicalactivity AT nyukats submergedcultivationoflentinusedodesstrainwithbroadspectrumbiologicalactivity AT aiusov submergedcultivationoflentinusedodesstrainwithbroadspectrumbiologicalactivity AT avbarkov submergedcultivationoflentinusedodesstrainwithbroadspectrumbiologicalactivity AT vavinokurov submergedcultivationoflentinusedodesstrainwithbroadspectrumbiologicalactivity |