The role of glycoproteins in nasopharyngeal carcinoma pathogenesis
Nasopharyngeal carcinoma (NPC) is a malignant tumor arising from the nasopharyngeal epithelium. It consists of undifferentiated squamous cells in the nasopharynx. This type of epithelial cell neoplasm is globally distributed, with the highest prevalence observed in certain regions of the world. It h...
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Editorial Office of Journal of Guangxi Medical University
2024-09-01
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| Series: | Guangxi Yike Daxue xuebao |
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| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.09.005 |
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| author | Liudmila Matskova Elvira Grigorieva |
| author_facet | Liudmila Matskova Elvira Grigorieva |
| author_sort | Liudmila Matskova |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma (NPC) is a malignant tumor arising from the nasopharyngeal epithelium. It consists of undifferentiated squamous cells in the nasopharynx. This type of epithelial cell neoplasm is globally distributed, with the highest prevalence observed in certain regions of the world. It has been known since ancient times. The incidence of NPC is steadily decreasing as data on the molecular factors involved in the pathogenesis of NPC accumulate. Glycoproteins are characterized by polymers of saccharides attached to the amino acid sequences of proteins during the process of glycosylation. They are present in all animal cells and are especially abundant on the surface of tumor cells. Alterations in expression of cellular glycoproteins have recently attracted attention as a key component of neoplastic progression. Tumor-associated glycoproteins may serve as a hallmark of cancer cells and thus represent novel diagnostic and even therapeutic targets. Interest in the role of glycoproteins in cancer in general and specifically in NPC pathology has steadily increased over the past fifty years, reaching over thousands and two hundred publications in the last five years, respectively. Here, data on a specific class of proteins, glycoproteins, involved in tumorigenesis of NPCs are summarized, with a focus on a few of the best-studied ones. Relevant studies performed mainly in the last five years were retrieved and collected through the PubMed system. |
| format | Article |
| id | doaj-art-ad4f4ac152bc4da78475196b2ac3d018 |
| institution | DOAJ |
| issn | 1005-930X |
| language | zho |
| publishDate | 2024-09-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-ad4f4ac152bc4da78475196b2ac3d0182025-08-20T02:57:28ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2024-09-014191261127210.16190/j.cnki.45-1211/r.2024.09.005gxykdxxb-41-9-1261The role of glycoproteins in nasopharyngeal carcinoma pathogenesisLiudmila Matskova0Elvira Grigorieva1Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine, Novosibirsk 630117, RussiaInstitute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine, Novosibirsk 630117, RussiaNasopharyngeal carcinoma (NPC) is a malignant tumor arising from the nasopharyngeal epithelium. It consists of undifferentiated squamous cells in the nasopharynx. This type of epithelial cell neoplasm is globally distributed, with the highest prevalence observed in certain regions of the world. It has been known since ancient times. The incidence of NPC is steadily decreasing as data on the molecular factors involved in the pathogenesis of NPC accumulate. Glycoproteins are characterized by polymers of saccharides attached to the amino acid sequences of proteins during the process of glycosylation. They are present in all animal cells and are especially abundant on the surface of tumor cells. Alterations in expression of cellular glycoproteins have recently attracted attention as a key component of neoplastic progression. Tumor-associated glycoproteins may serve as a hallmark of cancer cells and thus represent novel diagnostic and even therapeutic targets. Interest in the role of glycoproteins in cancer in general and specifically in NPC pathology has steadily increased over the past fifty years, reaching over thousands and two hundred publications in the last five years, respectively. Here, data on a specific class of proteins, glycoproteins, involved in tumorigenesis of NPCs are summarized, with a focus on a few of the best-studied ones. Relevant studies performed mainly in the last five years were retrieved and collected through the PubMed system.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.09.005nasopharyngeal carcinomaglycoproteinpathogenesis |
| spellingShingle | Liudmila Matskova Elvira Grigorieva The role of glycoproteins in nasopharyngeal carcinoma pathogenesis Guangxi Yike Daxue xuebao nasopharyngeal carcinoma glycoprotein pathogenesis |
| title | The role of glycoproteins in nasopharyngeal carcinoma pathogenesis |
| title_full | The role of glycoproteins in nasopharyngeal carcinoma pathogenesis |
| title_fullStr | The role of glycoproteins in nasopharyngeal carcinoma pathogenesis |
| title_full_unstemmed | The role of glycoproteins in nasopharyngeal carcinoma pathogenesis |
| title_short | The role of glycoproteins in nasopharyngeal carcinoma pathogenesis |
| title_sort | role of glycoproteins in nasopharyngeal carcinoma pathogenesis |
| topic | nasopharyngeal carcinoma glycoprotein pathogenesis |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.09.005 |
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