Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach
Background Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are the most common autoimmune diseases of the central nervous system (CNS). They present chronic relapsing courses that demand treatment with disease-modifying drugs (DMDs) to prevent inflammatory activity. Disea...
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Thieme Revinter Publicações
2022-10-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1754348 |
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| author | Ana Beatriz Ayroza Galvão Ribeiro Gomes Lucas Bueno Feo Guilherme Diogo Silva Caio César Diniz Disserol Renata Barbosa Paolilo Amanda Nazareth Lara Adriana Coracini Tonácio Maria Fernanda Mendes Samira Luísa Apóstolos Pereira Dagoberto Callegaro |
| author_facet | Ana Beatriz Ayroza Galvão Ribeiro Gomes Lucas Bueno Feo Guilherme Diogo Silva Caio César Diniz Disserol Renata Barbosa Paolilo Amanda Nazareth Lara Adriana Coracini Tonácio Maria Fernanda Mendes Samira Luísa Apóstolos Pereira Dagoberto Callegaro |
| author_sort | Ana Beatriz Ayroza Galvão Ribeiro Gomes |
| collection | DOAJ |
| description | Background Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are the most common autoimmune diseases of the central nervous system (CNS). They present chronic relapsing courses that demand treatment with disease-modifying drugs (DMDs) to prevent inflammatory activity. Disease-modifying drugs lead to immunomodulation or immunosuppression through diverse mechanisms (e.g., shifting lymphocyte and cytokine profile, suppressing specific lymphocyte subpopulations). Thus, patients are more prone to infectious complications and associated worsening of disease.
Objective To present feasible strategies for mitigating the infection risk of MS and NMOSD treated patients.
Methods Targeted literature review concerning the management of infection risk with an emphasis on vaccination, therapy-specific measures, and particularities of the Brazilian endemic infectious diseases' scenario.
Conclusion We propose a vaccination schedule, infectious screening routine, and prophylactic measures based on the current scientific evidence. Awareness of emergent tropical diseases is necessary due to evidence of demyelinating events and possible parainfectious cases of MS and NMOSD. |
| format | Article |
| id | doaj-art-ad4bdf9218024107bf955039befabef5 |
| institution | OA Journals |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-ad4bdf9218024107bf955039befabef52025-08-20T02:20:37ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272022-10-0180101057106610.1055/s-0042-1754348Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approachAna Beatriz Ayroza Galvão Ribeiro Gomes0Lucas Bueno Feo1Guilherme Diogo Silva2Caio César Diniz Disserol3Renata Barbosa Paolilo4Amanda Nazareth Lara5Adriana Coracini Tonácio6Maria Fernanda Mendes7Samira Luísa Apóstolos Pereira8Dagoberto Callegaro9Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Neurologia,, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Neurologia,, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Neurologia,, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Neurologia,, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Neurologia,, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Doenças Infecciosas e Parasitárias, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Doenças Infecciosas e Parasitárias, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Neurologia,, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Neurologia,, São Paulo SP, BrazilUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Neurologia,, São Paulo SP, BrazilBackground Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are the most common autoimmune diseases of the central nervous system (CNS). They present chronic relapsing courses that demand treatment with disease-modifying drugs (DMDs) to prevent inflammatory activity. Disease-modifying drugs lead to immunomodulation or immunosuppression through diverse mechanisms (e.g., shifting lymphocyte and cytokine profile, suppressing specific lymphocyte subpopulations). Thus, patients are more prone to infectious complications and associated worsening of disease. Objective To present feasible strategies for mitigating the infection risk of MS and NMOSD treated patients. Methods Targeted literature review concerning the management of infection risk with an emphasis on vaccination, therapy-specific measures, and particularities of the Brazilian endemic infectious diseases' scenario. Conclusion We propose a vaccination schedule, infectious screening routine, and prophylactic measures based on the current scientific evidence. Awareness of emergent tropical diseases is necessary due to evidence of demyelinating events and possible parainfectious cases of MS and NMOSD.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1754348multiple sclerosisneuromyelitis opticavaccines |
| spellingShingle | Ana Beatriz Ayroza Galvão Ribeiro Gomes Lucas Bueno Feo Guilherme Diogo Silva Caio César Diniz Disserol Renata Barbosa Paolilo Amanda Nazareth Lara Adriana Coracini Tonácio Maria Fernanda Mendes Samira Luísa Apóstolos Pereira Dagoberto Callegaro Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach Arquivos de Neuro-Psiquiatria multiple sclerosis neuromyelitis optica vaccines |
| title | Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach |
| title_full | Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach |
| title_fullStr | Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach |
| title_full_unstemmed | Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach |
| title_short | Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach |
| title_sort | reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders a brazilian reference center s approach |
| topic | multiple sclerosis neuromyelitis optica vaccines |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1754348 |
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