Treatment of chronic periodontitis using a preparation based on plant components in an experiment
Aim. Development of the chronic periodontitis treatment method using the medicamentation based on herbal components in the experiment.Materials and methods. An experimental model of chronic periodontitis was created. Mesenchymal stem cells (MSC) from the extracted retained human tooth were obtained...
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| Format: | Article |
| Language: | Russian |
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LLC "Endo Press"
2022-07-01
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| Series: | Эндодонтия Today |
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| Online Access: | https://www.endodont.ru/jour/article/view/1107 |
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| author | G. A. Valeeva R. R. Haibullina K. V. Danilko O. R. Shangina L. P. Gerasimova M. R. Shamsiev M. I. Astakhova I. A. Galiahmetova |
| author_facet | G. A. Valeeva R. R. Haibullina K. V. Danilko O. R. Shangina L. P. Gerasimova M. R. Shamsiev M. I. Astakhova I. A. Galiahmetova |
| author_sort | G. A. Valeeva |
| collection | DOAJ |
| description | Aim. Development of the chronic periodontitis treatment method using the medicamentation based on herbal components in the experiment.Materials and methods. An experimental model of chronic periodontitis was created. Mesenchymal stem cells (MSC) from the extracted retained human tooth were obtained multipotent. The obtained MSCs were injected into the periodontalpockets together with the osteogenesis stimulator drug. Then a medicamentation based on plant components was applied.Results. Periodontal pocket depth decreased to 1.5 ± 0.01 mm (P < 0.001). There was no tooth mobility. Three months after the therapeutic procedures radiographs of the rats showed signs of bone neoplasia. By 6 months these signs became more pronounced: the foci of stained osteoporosis disappeared and began to acquire a finely petrified structure, the contours of the interalveolar septa became clear and smooth with a simultaneous increase in the height of resorbed ridges of the interalveolar septa.Conclusions. Experimental studies have shown pronounced therapeutic efficacy of the method for the treatment of destructive changes of the alveolar bone in periodontitis. |
| format | Article |
| id | doaj-art-ad4a3fa7c5ba45ddb10af0787ccb925a |
| institution | Kabale University |
| issn | 1683-2981 1726-7242 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | LLC "Endo Press" |
| record_format | Article |
| series | Эндодонтия Today |
| spelling | doaj-art-ad4a3fa7c5ba45ddb10af0787ccb925a2025-08-20T03:59:02ZrusLLC "Endo Press"Эндодонтия Today1683-29811726-72422022-07-0120217918210.36377/1726-7242-2022-20-2-179-182979Treatment of chronic periodontitis using a preparation based on plant components in an experimentG. A. Valeeva0R. R. Haibullina1K. V. Danilko2O. R. Shangina3L. P. Gerasimova4M. R. Shamsiev5M. I. Astakhova6I. A. Galiahmetova7Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation«All-Russian Center for Eye and Plastic Surgery»Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian FederationAim. Development of the chronic periodontitis treatment method using the medicamentation based on herbal components in the experiment.Materials and methods. An experimental model of chronic periodontitis was created. Mesenchymal stem cells (MSC) from the extracted retained human tooth were obtained multipotent. The obtained MSCs were injected into the periodontalpockets together with the osteogenesis stimulator drug. Then a medicamentation based on plant components was applied.Results. Periodontal pocket depth decreased to 1.5 ± 0.01 mm (P < 0.001). There was no tooth mobility. Three months after the therapeutic procedures radiographs of the rats showed signs of bone neoplasia. By 6 months these signs became more pronounced: the foci of stained osteoporosis disappeared and began to acquire a finely petrified structure, the contours of the interalveolar septa became clear and smooth with a simultaneous increase in the height of resorbed ridges of the interalveolar septa.Conclusions. Experimental studies have shown pronounced therapeutic efficacy of the method for the treatment of destructive changes of the alveolar bone in periodontitis.https://www.endodont.ru/jour/article/view/1107multipotent mesenchymal stem cellspulpperiodontal ligament, periodontal ligament |
| spellingShingle | G. A. Valeeva R. R. Haibullina K. V. Danilko O. R. Shangina L. P. Gerasimova M. R. Shamsiev M. I. Astakhova I. A. Galiahmetova Treatment of chronic periodontitis using a preparation based on plant components in an experiment Эндодонтия Today multipotent mesenchymal stem cells pulp periodontal ligament, periodontal ligament |
| title | Treatment of chronic periodontitis using a preparation based on plant components in an experiment |
| title_full | Treatment of chronic periodontitis using a preparation based on plant components in an experiment |
| title_fullStr | Treatment of chronic periodontitis using a preparation based on plant components in an experiment |
| title_full_unstemmed | Treatment of chronic periodontitis using a preparation based on plant components in an experiment |
| title_short | Treatment of chronic periodontitis using a preparation based on plant components in an experiment |
| title_sort | treatment of chronic periodontitis using a preparation based on plant components in an experiment |
| topic | multipotent mesenchymal stem cells pulp periodontal ligament, periodontal ligament |
| url | https://www.endodont.ru/jour/article/view/1107 |
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