The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease
Objectives. The aims of this study were to evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers, and parameters from the complete blood count (CBC) in patients with inflammatory bowel disease (IBD) and their associations with disease activity. Methods. A total of 876 IBD pat...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/3467419 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547031635197952 |
|---|---|
| author | Yi-Han Chen Li Wang Shu-Yi Feng Wei-Min Cai Xiao-Fu Chen Zhi-Ming Huang |
| author_facet | Yi-Han Chen Li Wang Shu-Yi Feng Wei-Min Cai Xiao-Fu Chen Zhi-Ming Huang |
| author_sort | Yi-Han Chen |
| collection | DOAJ |
| description | Objectives. The aims of this study were to evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers, and parameters from the complete blood count (CBC) in patients with inflammatory bowel disease (IBD) and their associations with disease activity. Methods. A total of 876 IBD patients, composed of 275 patients with ulcerative colitis (UC) and 601 patients with Crohn’s disease (CD), were included in this retrospective study, and the serum C-reactive protein (CRP), albumin (ALB), erythrocyte sedimentation rate (ESR), and CBC parameters were measured. To explore the disease activity, the Mayo score and Crohn disease activity index were used to assess UC and CD patients, respectively. Results. The CRP/ALB ratio, CRP, ESR, platelet to lymphocyte ratio (PLR), red blood cell distribution width (RDW), and neutrophil to lymphocyte ratio (NLR) levels in active IBD patients were significantly higher than those in inactive IBD patients, whereas ALB and lymphocyte to monocyte ratio (LMR) levels were significantly decreased (P<0.001). The receiver operating characteristic analysis showed that the optimum cut-off values of the CRP/ALB ratio for active UC and CD were 0.18 and 0.43, with sensitivities of 67.8% and 75.8% and specificities of 86.7% and 92.0%, respectively. Multivariable logistic analysis revealed that after adjusting for these inflammatory markers (ESR, NLR, PLR, and LMR), the CRP/ALB ratio was a statistically significant parameter capable of differentiating the disease activity of UC and CD. Conclusions. This study indicated that the CRP/ALB ratio was closely related to the IBD disease activity. Compared with CBC parameters, the CRP/ALB ratio had a higher discriminative capacity for active IBD. |
| format | Article |
| id | doaj-art-ad45395b0aa14d8f9710543c1873f616 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ad45395b0aa14d8f9710543c1873f6162025-02-03T06:46:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/34674193467419The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel DiseaseYi-Han Chen0Li Wang1Shu-Yi Feng2Wei-Min Cai3Xiao-Fu Chen4Zhi-Ming Huang5Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaObjectives. The aims of this study were to evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers, and parameters from the complete blood count (CBC) in patients with inflammatory bowel disease (IBD) and their associations with disease activity. Methods. A total of 876 IBD patients, composed of 275 patients with ulcerative colitis (UC) and 601 patients with Crohn’s disease (CD), were included in this retrospective study, and the serum C-reactive protein (CRP), albumin (ALB), erythrocyte sedimentation rate (ESR), and CBC parameters were measured. To explore the disease activity, the Mayo score and Crohn disease activity index were used to assess UC and CD patients, respectively. Results. The CRP/ALB ratio, CRP, ESR, platelet to lymphocyte ratio (PLR), red blood cell distribution width (RDW), and neutrophil to lymphocyte ratio (NLR) levels in active IBD patients were significantly higher than those in inactive IBD patients, whereas ALB and lymphocyte to monocyte ratio (LMR) levels were significantly decreased (P<0.001). The receiver operating characteristic analysis showed that the optimum cut-off values of the CRP/ALB ratio for active UC and CD were 0.18 and 0.43, with sensitivities of 67.8% and 75.8% and specificities of 86.7% and 92.0%, respectively. Multivariable logistic analysis revealed that after adjusting for these inflammatory markers (ESR, NLR, PLR, and LMR), the CRP/ALB ratio was a statistically significant parameter capable of differentiating the disease activity of UC and CD. Conclusions. This study indicated that the CRP/ALB ratio was closely related to the IBD disease activity. Compared with CBC parameters, the CRP/ALB ratio had a higher discriminative capacity for active IBD.http://dx.doi.org/10.1155/2020/3467419 |
| spellingShingle | Yi-Han Chen Li Wang Shu-Yi Feng Wei-Min Cai Xiao-Fu Chen Zhi-Ming Huang The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease Gastroenterology Research and Practice |
| title | The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease |
| title_full | The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease |
| title_fullStr | The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease |
| title_short | The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease |
| title_sort | relationship between c reactive protein albumin ratio and disease activity in patients with inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2020/3467419 |
| work_keys_str_mv | AT yihanchen therelationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT liwang therelationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT shuyifeng therelationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT weimincai therelationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT xiaofuchen therelationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT zhiminghuang therelationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT yihanchen relationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT liwang relationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT shuyifeng relationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT weimincai relationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT xiaofuchen relationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease AT zhiminghuang relationshipbetweencreactiveproteinalbuminratioanddiseaseactivityinpatientswithinflammatoryboweldisease |