Complement C3 inhibition reduces complement activation in clinical platelet concentrates but does not counteract platelet storage lesions

Complement C3 inhibition reduces complement activation in clinical platelet concentrates but does not counteract platelet storage lesions

Platelet storage is associated with storage lesions, including platelet morphological changes and a gradual functional loss. We investigated the impact of complement C3 inhibition on complement activation and platelet storage lesions in clinical platelet concentrates. Platelet concentrates (n = 8) w...

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Bibliographic Details
Main Authors: Linnea I. Andersson, Per Sandgren, Dick J. Sjöström, Camilla Mohlin, Kim Hägerström, Ivar Tjernberg, Tom Eirik Mollnes, Per H. Nilsson
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Platelets
Subjects:
Complement
complement inhibition
platelet concentrates
platelet storage lesions
platelet transfusion
platelets
Online Access:https://www.tandfonline.com/doi/10.1080/09537104.2025.2513298
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