Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats
Palm oil is a component of most food products, characterized by a high content of palmitic and oleic acids, an excess of which leads to the formation of tripalmitins, practically do not respond to enzymatic hydrolysis by lipoprotein lipase and predetermine the development of obesity, type 2 diabetes...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2024-01-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/389 |
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| author | T. E. Bogacheva A. G. Kalacheva O. A. Gromova I. Yu. Torshin T. R. Grishina V. I. Demidov |
| author_facet | T. E. Bogacheva A. G. Kalacheva O. A. Gromova I. Yu. Torshin T. R. Grishina V. I. Demidov |
| author_sort | T. E. Bogacheva |
| collection | DOAJ |
| description | Palm oil is a component of most food products, characterized by a high content of palmitic and oleic acids, an excess of which leads to the formation of tripalmitins, practically do not respond to enzymatic hydrolysis by lipoprotein lipase and predetermine the development of obesity, type 2 diabetes mellitus and atherosclerosis. This paper presents the results of a study of the drug Laennek, produced on the basis of standardized hydrolysates of the human placenta (HRP). The use of HRP under the influence of excessive consumption of palm oil in the diet led to a significant decrease in markers of liver dysfunction (ALT), which increase with an enriched diet of refined palm oil (bilirubin, total protein, ALT, AST). The hepatoprotective effect of Laennek was confirmed by the results of histological and biochemical studies indicating a decrease in the severity and prevalence of fatty liver dystrophy. |
| format | Article |
| id | doaj-art-ad42e4c42de74c6bb8dd7c7f16dada50 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-ad42e4c42de74c6bb8dd7c7f16dada502025-08-20T03:42:33ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302024-01-0104233110.37489/2587-7836-2023-4-23-31352Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in ratsT. E. Bogacheva0A. G. Kalacheva1O. A. Gromova2I. Yu. Torshin3T. R. Grishina4V. I. Demidov5FSBEI HE "Ivanovo State Medical Academy" MOH RussiaFSBEI HE "Ivanovo State Medical Academy" MOH RussiaFRC "Computer Science and Control" RASFRC "Computer Science and Control" RASFSBEI HE "Ivanovo State Medical Academy" MOH RussiaFSBEI HE "Ivanovo State Medical Academy" MOH RussiaPalm oil is a component of most food products, characterized by a high content of palmitic and oleic acids, an excess of which leads to the formation of tripalmitins, practically do not respond to enzymatic hydrolysis by lipoprotein lipase and predetermine the development of obesity, type 2 diabetes mellitus and atherosclerosis. This paper presents the results of a study of the drug Laennek, produced on the basis of standardized hydrolysates of the human placenta (HRP). The use of HRP under the influence of excessive consumption of palm oil in the diet led to a significant decrease in markers of liver dysfunction (ALT), which increase with an enriched diet of refined palm oil (bilirubin, total protein, ALT, AST). The hepatoprotective effect of Laennek was confirmed by the results of histological and biochemical studies indicating a decrease in the severity and prevalence of fatty liver dystrophy.https://www.pharmacokinetica.ru/jour/article/view/389palm oilsteatohepatosishuman placenta hydrolysateslaennechepatoprotection |
| spellingShingle | T. E. Bogacheva A. G. Kalacheva O. A. Gromova I. Yu. Torshin T. R. Grishina V. I. Demidov Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats Фармакокинетика и Фармакодинамика palm oil steatohepatosis human placenta hydrolysates laennec hepatoprotection |
| title | Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats |
| title_full | Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats |
| title_fullStr | Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats |
| title_full_unstemmed | Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats |
| title_short | Study of the effectiveness of the drug Laennek in case of liver damage by palm oil in rats |
| title_sort | study of the effectiveness of the drug laennek in case of liver damage by palm oil in rats |
| topic | palm oil steatohepatosis human placenta hydrolysates laennec hepatoprotection |
| url | https://www.pharmacokinetica.ru/jour/article/view/389 |
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